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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-EIF5A antibody (1-100) [S6MR] (STJ11102076)

  • 產(chǎn)品型號：STJ11102076
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
Anti-EIF5A antibody (1-100) [S6MR] (STJ11102076)
詳情介紹：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-eIF5A (1-100) is suitable for use in Western Blot research applications.
Clonality: Monoclonal
Clone ID: S6MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EIF5A
Gene ID: 1984
Uniprot ID: IF5A1_HUMAN
Immunogen Region: 1-100
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human eIF5A (P63241).
Immunogen Sequence: MADDLDFETGDAGASATFPM QCSALRKNGFVVLKGRPCKI VEMSTSKTGKHGHAKVHLVG IDIFTGKKYEDICPSTHNMD VPNIKRNDFQLIGIQDGYLS
Tissue Specificity Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level).
Post Translational Modifications Acetylated by PCAF/KAT2B, regulating its subcellular localization. Deacetylated by SIRT2. Lys-50 undergoes hypusination, a unique post-translational modification that consists in the addition of a butylamino group from spermidine to lysine side chain, leading to the formation of the unusual amino acid hypusine. eIF-5As are the only known proteins to undergo this modification, which is essential for their function.
Function Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step. Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. (Microbial infection) Cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.
Protein Name Eukaryotic Translation Initiation Factor 5a-1
Eif-5a-1
Eif-5a1
Eukaryotic Initiation Factor 5a Isoform 1
Eif-5a
Rev-Binding Factor
Eif-4d
Database Links Reactome: R-HSA-204626
Cellular Localisation Cytoplasm
Nucleus
Endoplasmic Reticulum Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Hypusine Modification Promotes The Nuclear Export And Cytoplasmic Localization And There Was A Dynamic Shift In The Localization From Predominantly Cytoplasmic To Primarily Nuclear Under Apoptotic Inducing Conditions
Nuclear Export Of Hypusinated Protein Is Mediated By Xpo4
Alternative Antibody Names Anti-Eukaryotic Translation Initiation Factor 5a-1 antibody
Anti-Eif-5a-1 antibody
Anti-Eif-5a1 antibody
Anti-Eukaryotic Initiation Factor 5a Isoform 1 antibody
Anti-Eif-5a antibody
Anti-Rev-Binding Factor antibody
Anti-Eif-4d antibody
Anti-EIF5A antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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