產(chǎn)品詳情
簡單介紹：
Anti-EIF4G1 antibody (400-500) (STJ116294)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-EIF4G (400-500) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000 IHC-P 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EIF4G1 |
| Gene ID: | 1981 |
| Uniprot ID: | IF4G1_HUMAN |
| Immunogen Region: | 400-500 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 400-500 of human EIF4G1 (NP_886553.3). |
| Immunogen Sequence: | PEELLNGAPSPPAVDLSPVS EPEEQAKEVTASMAPPTIPS ATPATAPSATSPAQEEEMEE EEEEEEGEAGEAGEAESEKG GEELLPPESTPIPANLSQNL E |
| Post Translational Modifications | Phosphorylated at multiple sites in vivo. Phosphorylation at Ser-1185 by PRKCA induces binding to MKNK1. Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription. |
| Function | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon. Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation. |
| Protein Name | Eukaryotic Translation Initiation Factor 4 Gamma 1 Eif-4-Gamma 1 Eif-4g 1 Eif-4g1 P220 |
| Database Links | Reactome: R-HSA-1169408 Reactome: R-HSA-156827 Reactome: R-HSA-166208 Reactome: R-HSA-429947 Reactome: R-HSA-450408 Reactome: R-HSA-72649 Reactome: R-HSA-72662 Reactome: R-HSA-72702 Reactome: R-HSA-72706 Reactome: R-HSA-9010553 Reactome: R-HSA-975956 Reactome: R-HSA-975957 |
| Cellular Localisation | Cytoplasm Nucleus Stress Granule |
| Alternative Antibody Names | Anti-Eukaryotic Translation Initiation Factor 4 Gamma 1 antibody Anti-Eif-4-Gamma 1 antibody Anti-Eif-4g 1 antibody Anti-Eif-4g1 antibody Anti-P220 antibody Anti-EIF4G1 antibody Anti-EIF4F antibody Anti-EIF4G antibody Anti-EIF4GI antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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