產品詳情
簡單介紹：
Mouse NRG-1 (Neuregulin 1) Sandwich ELISA (STJE0004267)
詳情介紹：
| Applications: | ELISA |
| Reactivity: | Mouse |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Sensitivity: | 46.88pg/mL |
| Detection Limit: | 78.13~5000pg/mL |
| Short Description: | This NRG-1 Sandwich ELISA is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: | If unopened the kit may be stored at 2-8°C for up to 1 month. If the kit will not be used within 1 month, store the components separately, according to the component table in the manual. |
| Assay Time: | 3.5h |
| Detection: | Colormetric |
| Gene Symbol: | Nrg1Uniprot ID=NRG1_MOUSE" |
| Specificity: | This kit recognizes Mouse NRG-1 in samples. No significant cross-reactivity or interference between Mouse NRG-1 and analogues was observed. |
| Sample Type: | Serum, plasma and other biological fluids |
| Function | Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells.inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction.stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells.stimulating Schwann cell proliferation.implication in the development of the myocardium such as trabeculation of the developing heart. Binds to ERBB4 and ERBB3. Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1, and ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons. |
| Protein Name | Pro-Neuregulin-1 - Membrane-Bound Isoform Pro-Nrg1 Cleaved Into - Neuregulin-1 Acetylcholine Receptor-Inducing Activity Aria Glial Growth Factor Heregulin Hrg Neu Differentiation Factor Sensory And Motor Neuron-Derived Factor |
| Cellular Localisation | Pro-Neuregulin-1 Membrane-Bound Isoform: Cell Membrane Single-Pass Type I Membrane Protein Does Not Seem To Be Active Neuregulin-1: Secreted |
| Alternative ELISA Names | Pro-Neuregulin-1 - Membrane-Bound Isoform ELISA kit Pro-Nrg1 Cleaved Into - Neuregulin-1 ELISA kit Acetylcholine Receptor-Inducing Activity ELISA kit Aria ELISA kit Glial Growth Factor ELISA kit Heregulin ELISA kit Hrg ELISA kit Neu Differentiation Factor ELISA kit Sensory And Motor Neuron-Derived Factor ELISA kit Nrg1 ELISA kit |
| Specificity | This kit recognizes Mouse NRG-1 in samples. No significant cross-reactivity or interference between Mouse NRG-1 and analogues was observed. |
| Reproducibility | Both intra-CV and inter-CV are |
Information sourced from Uniprot.org
| Micro ELISA Plate (Dismountable) | 96T: 8 wells ×12 strips strips | -20℃, 6 months |
| Reference Standard | 96T: 2 vials 48T: 1 vial | -20℃, 6 months |
| Concentrated Biotinylated Detection Ab (100×) | 96T: 1 vial, 120 μL 60 μL | -20℃, 6 months |
| Concentrated HRP Conjugate (100×) | 96T: 1 vial, 120 μL 60 μL | -20℃ (Protect from light), 6 months |
| Reference Standard & Sample Diluent | 1 vial, 20 mL | 2-8°C, 6 months |
| Biotinylated Detection Ab Diluent | 1 vial, 14 mL | 2-8°C, 6 months |
| HRP Conjugate Diluent | 1 vial, 14 mL | 2-8°C, 6 months |
| Concentrated Wash Buffer (25×) | 1 vial, 30 mL | 2-8°C, 6 months |
| Substrate Reagent | 1 vial, 10 mL | 2-8℃ (Protect from light) |
| Stop Solution | 1 vial, 10 mL | 2-8°C |
| Plate Sealer | 5 pieces | |
| Manual | 1 copy | |
| Certificate of Analysis | 1 copy |
| Serum(n=8) | 92-108 | 99 |
| EDTA plasma (n=8) | 87-103 | 94 |
| Cell culture media (n=8) | 84-98 | 91 |
| Sample | 1.00 | 2.00 | 3.00 | 1.00 | 2.00 | 3.00 |
| n | 20.00 | 20.00 | 20.00 | 20.00 | 20.00 | 20.00 |
| Mean (pg/mL) | 269.17 | 647.17 | 1891.39 | 292.65 | 589.60 | 1945.51 |
| Standard deviation | 17.15 | 33.72 | 101.57 | 18.09 | 23.82 | 96.11 |
| CV (%) | 6.37 | 5.21 | 5.37 | 6.18 | 4.04 | 4.94 |
相關信息
![Anti-14-3-3 beta/Theta antibody (1-100) [S1MR] (STJ11103651)](http://y1.yzimgs.com/uploads/465546/2024520-20551366.png?imageView2/2/w/200/h/200)
- 細胞培養(yǎng)玄學-MRC-5細胞 2025-01-07
- Ocean NanoTech定制的詳細步驟 2021-10-31
- click chemistry tools數據結果比... 2021-10-31
- LaysanBio代理商相關文獻資料2020 2021-10-31
- Abbiotec代理的產品得到重復驗證2020 2021-10-31
- zyagen Laboratories代理的產品得到... 2021-06-20
- Toxin Technologies代理商相關文獻資... 2021-03-14
- 熱烈祝賀玉博生物正式代理biocolor公司試劑產品... 2021-03-14
- 熱烈祝賀玉博生物正式代理cytognos公司試劑產品... 2021-03-14
- Gelest代理的產品得到重復驗證2020 2021-03-14
