產(chǎn)品詳情
簡單介紹：
Mouse NQO1 (NADH Dehydrogenase, Quinone 1) Sandwich ELISA Kit (STJE0011067)
詳情介紹：
| Applications: | ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.127ng/mL |
| Detection Limit: | 0.312-20ng/mL |
| Short Description: | This NQO1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | Nqo1 |
| Gene ID: | 18104 |
| Uniprot ID: | NQO1_MOUSE |
| Sample Type: | tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | |
| Function | Flavin-containing quinone reductase that catalyzes two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to flavin cofactor and then from reduced flavin to the quinone, bypassing the formation of semiquinone and reactive oxygen species. Regulates cellular redox state primarily through quinone detoxification. Reduces components of plasma membrane redox system such as coenzyme Q and vitamin quinones, producing antioxidant hydroquinone forms. In the process may function as superoxide scavenger to prevent hydroquinone oxidation and facilitate excretion. Alternatively, can activate quinones and their derivatives by generating redox reactive hydroquinones with DNA cross-linking antitumor potential. Acts as a gatekeeper of the core 20S proteasome known to degrade proteins with unstructured regions. Upon oxidative stress, interacts with tumor suppressors TP53 and TP73 in a NADH-dependent way and inhibits their ubiquitin-independent degradation by the 20S proteasome. |
| Protein Name | Nad(Ph Dehydrogenase Quinone 1 Azoreductase Dt-Diaphorase Dtd Menadione Reductase Nad(Ph -Quinone Oxidoreductase 1 Phylloquinone Reductase Quinone Reductase 1 Qr1 |
| Database Links | Reactome: R-MMU-350562 |
| Cellular Localisation | Cytoplasm Cytosol |
| Alternative ELISA Names | Nad(Ph Dehydrogenase Quinone 1 ELISA kit Azoreductase ELISA kit Dt-Diaphorase ELISA kit Dtd ELISA kit Menadione Reductase ELISA kit Nad(Ph -Quinone Oxidoreductase 1 ELISA kit Phylloquinone Reductase ELISA kit Quinone Reductase 1 ELISA kit Qr1 ELISA kit Nqo1 ELISA kit Dia4 ELISA kit Nmo1 ELISA kit Nmor1 ELISA kit |
| output |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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