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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-EIF3G antibody (1-320) (STJ23512)

  • 產(chǎn)品型號：STJ23512
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
Anti-EIF3G antibody (1-320) (STJ23512)
詳情介紹：
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-EIF3G (1-320) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:200-1:2000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EIF3G
Gene ID: 8666
Uniprot ID: EIF3G_HUMAN
Immunogen Region: 1-320
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-320 of human EIF3G (NP_003746.2).
Immunogen Sequence: MPTGDFDSKPSWADQVEEEG EDDKCVTSELLKGIPLATGD TSPEPELLPGAPLPPPKEVI NGNIKTVTEYKIDEDGKKFK IVRTFRIETRKASKAVARRK NWKKFGNSEFDPPGPNVATT TVSDDVSMTFITSKEDLNCQ EEEDPMNKLKGQKIVSCRIC KGDHWTTRCPYKDTLGPMQK ELAEQLGLSTGEKEKLPGEL EPVQATQNKTGKYVPPSLRD GASRRGESMQPNRRADDNA
Post Translational Modifications Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
Function RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA. (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2.
Protein Name Eukaryotic Translation Initiation Factor 3 Subunit G
Eif3g
Eukaryotic Translation Initiation Factor 3 Rna-Binding Subunit
Eif-3 Rna-Binding Subunit
Eukaryotic Translation Initiation Factor 3 Subunit 4
Eif-3-Delta
Eif3 P42
Eif3 P44
Database Links Reactome: R-HSA-156827
Reactome: R-HSA-72649
Reactome: R-HSA-72689
Reactome: R-HSA-72695
Reactome: R-HSA-72702
Reactome: R-HSA-72706
Cellular Localisation Cytoplasm
Nucleus
Perinuclear Region
Colocalizes With Aifm1 In The Nucleus And Perinuclear Region
Alternative Antibody Names Anti-Eukaryotic Translation Initiation Factor 3 Subunit G antibody
Anti-Eif3g antibody
Anti-Eukaryotic Translation Initiation Factor 3 Rna-Binding Subunit antibody
Anti-Eif-3 Rna-Binding Subunit antibody
Anti-Eukaryotic Translation Initiation Factor 3 Subunit 4 antibody
Anti-Eif-3-Delta antibody
Anti-Eif3 P42 antibody
Anti-Eif3 P44 antibody
Anti-EIF3G antibody
Anti-EIF3S4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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