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產品詳情

  • 產品名稱：Anti-EIF3F antibody (88-357) (STJ29103)

  • 產品型號：STJ29103
  • 產品廠商：ST john's laboratory
  • 產品文檔：
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簡單介紹：
Anti-EIF3F antibody (88-357) (STJ29103)
詳情介紹：
Host: Rabbit
Applications: WB/IF/IP
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-EIF3F (88-357) is suitable for use in Western Blot, Immunofluorescence and Immunoprecipitation research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IF/ICC 1:50-1:200
IP 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EIF3F
Gene ID: 8665
Uniprot ID: EIF3F_HUMAN
Immunogen Region: 88-357
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 88-357 of human EIF3F (NP_003745.1).
Immunogen Sequence: GGRVVRLHPVILASIVDSYE RRNEGAARVIGTLLGTVDKH SVEVTNCFSVPHNESEDEVA VDMEFAKNMYELHKKVSPNE LILGWYATGHDITEHSVLIH EYYSREAPNPIHLTVDTSLQ NGRMSIKAYVSTLMGVPGRT MGVMFTPLTVKYAYYDTERI GVDLIMKTCFSPNRVIGLSS DLQQVGGASARIQDALSTVL QYAEDVLSGKVSADNTVGRF LMSLVNQVPKIVPDDFETM
Post Translational Modifications Phosphorylation is enhanced upon serum stimulation. Phosphorylated during apoptosis by caspase-processed CDK11.
Function Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling.
Protein Name Eukaryotic Translation Initiation Factor 3 Subunit F
Eif3f
Deubiquitinating Enzyme Eif3f
Eukaryotic Translation Initiation Factor 3 Subunit 5
Eif-3-Epsilon
Eif3 P47
Database Links Reactome: R-HSA-156827
Reactome: R-HSA-72649
Reactome: R-HSA-72689
Reactome: R-HSA-72695
Reactome: R-HSA-72702
Reactome: R-HSA-72706
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Eukaryotic Translation Initiation Factor 3 Subunit F antibody
Anti-Eif3f antibody
Anti-Deubiquitinating Enzyme Eif3f antibody
Anti-Eukaryotic Translation Initiation Factor 3 Subunit 5 antibody
Anti-Eif-3-Epsilon antibody
Anti-Eif3 P47 antibody
Anti-EIF3F antibody
Anti-EIF3S5 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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