產(chǎn)品詳情
簡單介紹：
Mouse NOX4 (Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4) Sandwich ELISA Kit (STJE0011025)
詳情介紹：
| Applications: | ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.067ng/mL |
| Detection Limit: | 0.156-10ng/mL |
| Short Description: | This NOX4 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | Nox4 |
| Gene ID: | 50490 |
| Uniprot ID: | NOX4_MOUSE |
| Sample Type: | tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | EXpressed in brain, in all layers of the cerebellum, in pyramidal cells of the Ammon horn and in Purkinje cells (at protein level). Expressed in osteoclasts, leukocytes, kidney, liver and lung. |
| Post Translational Modifications | N-glycosylation is required for the function. |
| Function | Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. |
| Protein Name | Nadph Oxidase 4 Kidney Oxidase-1 Kox-1 Kidney Superoxide-Producing Nadph Oxidase Renal Nad(Ph-Oxidase Superoxide-Generating Nadph Oxidase 4 |
| Database Links | Reactome: R-MMU-3299685 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Cell Junction Focal Adhesion Cell Membrane May Localize To Plasma Membrane And Focal Adhesions |
| Alternative ELISA Names | Nadph Oxidase 4 ELISA kit Kidney Oxidase-1 ELISA kit Kox-1 ELISA kit Kidney Superoxide-Producing Nadph Oxidase ELISA kit Renal Nad(Ph-Oxidase ELISA kit Superoxide-Generating Nadph Oxidase 4 ELISA kit Nox4 ELISA kit Renox ELISA kit |
| output |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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