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產(chǎn)品詳情

  • 產(chǎn)品名稱：Mouse NFATC1 (Nuclear Factor Of Activated T-Cells, Cytoplasmic 1) Sandwich ELISA Kit (STJE0010934)

  • 產(chǎn)品型號(hào)：STJE0010934
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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Mouse NFATC1 (Nuclear Factor Of Activated T-Cells, Cytoplasmic 1) Sandwich ELISA Kit (STJE0010934)
詳情介紹：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.055ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This NFATC1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Nfatc1Uniprot ID=NFAC1_MOUSE"
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Expressed in the submandibular gland (at protein level). Expressed in basal epidermal cells (at protein level). Expressed in spleen, lung, skeletal muscle, thymus and skin. Weakly expressed in heart, brain, liver and kidney. Not expressed in testis. Expressed in osteoclasts. Also expressed during TNFSF11/RANKL-induced differentiation of bone marrow-derived macrophages to osteoclasts.
Post Translational Modifications Phosphorylated by NFATC-kinase and GSK3B.phosphorylation induces NFATC1 nuclear exit and dephosphorylation by calcineurin promotes nuclear import. Phosphorylation by PKA and DYRK2 negatively modulates nuclear accumulation, and promotes subsequent phosphorylation by GSK3B or casein kinase 1.
Function Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function.
Protein Name Nuclear Factor Of Activated T-Cells - Cytoplasmic 1
Nf-Atc1
Nfatc1
Nfat Transcription Complex Cytosolic Component
Nf-Atc
Nfatc
Database Links
Cellular Localisation Cytoplasm
Nucleus
Cytoplasmic For The Phosphorylated Form And Nuclear After Activation That Is Controlled By Calcineurin-Mediated Dephosphorylation
Rapid Nuclear Exit Of Nfatc Is Thought To Be One Mechanism By Which Cells Distinguish Between Sustained And Transient Calcium Signals
The Subcellular Localization Of Nfatc Plays A Key Role In The Regulation Of Gene Transcription
Nuclear Translocation Of Nfatc1 Is Enhanced In The Presence Of Tnfsf11
Nuclear Translocation Is Decreased In The Presence Of Fbn1 Which Can Bind And Sequester Tnfsf11
Alternative ELISA Names Nuclear Factor Of Activated T-Cells - Cytoplasmic 1 ELISA kit
Nf-Atc1 ELISA kit
Nfatc1 ELISA kit
Nfat Transcription Complex Cytosolic Component ELISA kit
Nf-Atc ELISA kit
Nfatc ELISA kit
Nfatc1 ELISA kit
Nfat2 ELISA kit
Nfatc ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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