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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-EIF3A antibody (1-250) (STJ29809)

  • 產(chǎn)品型號(hào)：STJ29809
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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Anti-EIF3A antibody (1-250) (STJ29809)
詳情介紹：
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-EIF3A (1-250) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:5000
IF/ICC 1:50-1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EIF3A
Gene ID: 8661
Uniprot ID: EIF3A_HUMAN
Immunogen Region: 1-250
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human EIF3A (NP_003741.1).
Immunogen Sequence: MPAYFQRPENALKRANEFLE VGKKQPALDVLYDVMKSKKH RTWQKIHEPIMLKYLELCVD LRKSHLAKEGLYQYKNICQQ VNIKSLEDVVRAYLKMAEEK TEAAKEESQQMVLDIEDLDN IQTPESVLLSAVSGEDTQDR TDRLLLTPWVKFLWESYRQC LDLLRNNSRVERLYHDIAQQ AFKFCLQYTRKAEFRKLCDN LRMHLSQIQRHHNQSTAINL NNPESQSMHLETRLVQLDS
Post Translational Modifications Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
Function RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation. (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2.
Protein Name Eukaryotic Translation Initiation Factor 3 Subunit A
Eif3a
Eukaryotic Translation Initiation Factor 3 Subunit 10
Eif-3-Theta
Eif3 P167
Eif3 P180
Eif3 P185
Database Links Reactome: R-HSA-156827
Reactome: R-HSA-72649
Reactome: R-HSA-72689
Reactome: R-HSA-72695
Reactome: R-HSA-72702
Reactome: R-HSA-72706
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Eukaryotic Translation Initiation Factor 3 Subunit A antibody
Anti-Eif3a antibody
Anti-Eukaryotic Translation Initiation Factor 3 Subunit 10 antibody
Anti-Eif-3-Theta antibody
Anti-Eif3 P167 antibody
Anti-Eif3 P180 antibody
Anti-Eif3 P185 antibody
Anti-EIF3A antibody
Anti-EIF3S10 antibody
Anti-KIAA0139 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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