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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-EIF2S1 antibody (21-70 aa) (STJ92872)

  • 產(chǎn)品型號(hào)：STJ92872
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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Anti-EIF2S1 antibody (21-70 aa) (STJ92872)
詳情介紹：
Host: Rabbit
Applications: IF/WB/IHC/ELISA
Reactivity: Human/Mouse/Rat/Monkey/Fish
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Eukaryotic translation initiation factor 2 subunit 1 (21-70 aa) is suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IF 1:50-200
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EIF2S1
Gene ID: 1965
Uniprot ID: IF2A_HUMAN
Immunogen Region: 21-70 aa
Specificity: eIF2 Alpha Polyclonal Antibody detects endogenous levels of eIF2 Alpha protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human eIF2 alpha at the amino acid range 21-70
Function Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. EIF2S1/eIF2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF2-alpha in a global protein synthesis inhibitor, leading to an attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming.
Protein Name Eukaryotic Translation Initiation Factor 2 Subunit 1
Eukaryotic Translation Initiation Factor 2 Subunit Alpha
Eif-2-Alpha
Eif-2a
Eif-2alpha
Eif2-Alpha
Database Links Reactome: R-HSA-156827
Reactome: R-HSA-381042
Reactome: R-HSA-382556
Reactome: R-HSA-72649
Reactome: R-HSA-72695
Reactome: R-HSA-72702
Reactome: R-HSA-72706
Reactome: R-HSA-72731
Reactome: R-HSA-9633012
Reactome: R-HSA-9648895
Cellular Localisation Cytoplasm
Stress Granule
Colocalizes With Nanos3 In The Stress Granules
Alternative Antibody Names Anti-Eukaryotic Translation Initiation Factor 2 Subunit 1 antibody
Anti-Eukaryotic Translation Initiation Factor 2 Subunit Alpha antibody
Anti-Eif-2-Alpha antibody
Anti-Eif-2a antibody
Anti-Eif-2alpha antibody
Anti-Eif2-Alpha antibody
Anti-EIF2S1 antibody
Anti-EIF2A antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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