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產(chǎn)品名稱：Anti-eIF2C3 antibody (721-860) [S9MR] (STJ11103159)
產(chǎn)品型號：STJ11103159
產(chǎn)品廠商：ST john's laboratory
產(chǎn)品文檔：

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簡單介紹：

Anti-eIF2C3 antibody (721-860) [S9MR] (STJ11103159)

詳情介紹：

Host:	Rabbit
Applications:	WB/IHC
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-eIF2C3 (721-860) is suitable for use in Western Blot and Immunohistochemistry research applications.

Clonality:	Monoclonal
Clone ID:	S9MR
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IHC-P 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	AGO3
Gene ID:	192669
Uniprot ID:	AGO3_HUMAN
Immunogen Region:	721-860
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 721-860 of human eIF2C3 (Q9H9G7).
Immunogen Sequence:	RTERVGRSGNIPAGTTVDTD ITHPYEFDFYLCSHAGIQGT SRPSHYHVLWDDNCFTADEL QLLTYQLCHTYVRCTRSVSI PAPAYYAHLVAFRARYHLVD KEHDSAEGSHVSGQSNGRDP QALAKAVQIHQDTLRTMYFA

Post Translational Modifications	Ubiquitinated on surface-exposed lysines by a SCF-like E3 ubiquitin-protein ligase complex containing ZSWIM8 during target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs). Ubiquitination by the SCF-like E3 ubiquitin-protein ligase complex containing ZSWIM8 leads to its subsequent degradation, thereby exposing miRNAs for degradation. ZSWIM8 recognizes and binds AGO3 when it is engaged with a TDMD target.
Function	Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity.
Protein Name	Protein Argonaute-3 Argonaute3 Hago3 Argonaute Risc Catalytic Component 3 Eukaryotic Translation Initiation Factor 2c 3 Eif-2c 3 Eif2c 3
Database Links	Reactome: R-HSA-1912408 Reactome: R-HSA-203927 Reactome: R-HSA-2559580 Reactome: R-HSA-2559585 Reactome: R-HSA-4086398 Reactome: R-HSA-426486 Reactome: R-HSA-426496 Reactome: R-HSA-5628897 Reactome: R-HSA-5687128 Reactome: R-HSA-8853884 Reactome: R-HSA-8934593 Reactome: R-HSA-8936459 Reactome: R-HSA-8943723 Reactome: R-HSA-8948700 Reactome: R-HSA-8986944 Reactome: R-HSA-9018519 Reactome: R-HSA-9022692 Reactome: R-HSA-9029569 Reactome: R-HSA-9759811 Reactome: R-HSA-9768778
Cellular Localisation	Cytoplasm P-Body
Alternative Antibody Names	Anti-Protein Argonaute-3 antibody Anti-Argonaute3 antibody Anti-Hago3 antibody Anti-Argonaute Risc Catalytic Component 3 antibody Anti-Eukaryotic Translation Initiation Factor 2c 3 antibody Anti-Eif-2c 3 antibody Anti-Eif2c 3 antibody Anti-AGO3 antibody Anti-EIF2C3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產(chǎn)品名稱：Anti-eIF2C3 antibody (721-860) [S9MR] (STJ11103159)