產(chǎn)品詳情
簡(jiǎn)單介紹:
Mouse MUC4 (Mucin 4) Sandwich ELISA Kit (STJE0010788)
詳情介紹:
Applications: | ELISA |
Reactivity: | Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Sensitivity: | 0.087ng/mL |
Detection Limit: | 0.312-20ng/mL |
Short Description: | This MUC4 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
Assay Time: | 4.5 hrs |
Gene Symbol: | Muc4 |
Gene ID: | 140474 |
Uniprot ID: | MUC4_MOUSE |
Sample Type: | tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Tissue Specificity | Expressed in trachea, duodenum and intestine. Lower expression in stomach, salivary glands, liver, gallbladder, and kidney. |
Post Translational Modifications | Proteolytically cleaved into 2 chains, mucin-4 alpha chain and mucin-4 beta chain. Mucin-4 alpha chain: Highly O-glycosylated. Mucin-4 beta chain: Predominantly N-glycosylated. |
Function | Membrane-bound mucin, a family of highly glycosylated proteins that constitute the major component of the mucus, the slimy and viscous secretion covering epithelial surfaces. These glycoproteins play important roles in the protection of the epithelium and are implicated in epithelial renewal and differentiation. Regulates cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as an intramembrane ligand for ERBB2. Plays an important role in proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. In polarized epithelial cells, segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. Its ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. |
Protein Name | Mucin-4 Muc-4 Ascites Sialoglycoprotein Asgp Pancreatic Adenocarcinoma Mucin Testis Mucin Cleaved Into - Mucin-4 Alpha Chain Ascites Sialoglycoprotein 1 Asgp-1 - Mucin-4 Beta Chain Ascites Sialoglycoprotein 2 Asgp-2 |
Database Links | Reactome: R-MMU-913709 Reactome: -MMU-977068 |
Cellular Localisation | Mucin-4 Beta Chain: Cell Membrane Single-Pass Membrane Protein Isoforms Lacking The Cys-Rich Region Egf-Like Domains And Transmembrane Region Are Secreted Secretion Occurs By Splicing Or Proteolytic Processing Mucin-4 Alpha Chain: Cell Membrane Secreted Forms A Complex With Mucin-4 Beta Chain At The Cell Membrane |
Alternative ELISA Names | Mucin-4 ELISA kit Muc-4 ELISA kit Ascites Sialoglycoprotein ELISA kit Asgp ELISA kit Pancreatic Adenocarcinoma Mucin ELISA kit Testis Mucin Cleaved Into - Mucin-4 Alpha Chain ELISA kit Ascites Sialoglycoprotein 1 ELISA kit Asgp-1 - Mucin-4 Beta Chain ELISA kit Ascites Sialoglycoprotein 2 ELISA kit Asgp-2 ELISA kit Muc4 ELISA kit |
output |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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