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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-EIF1AX antibody (10-144) (STJ27713)

  • 產(chǎn)品型號(hào)：STJ27713
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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Anti-EIF1AX antibody (10-144) (STJ27713)
詳情介紹：
Host: Rabbit
Applications: WB/IHC/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-EIF1AX (10-144) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:200-1:2000
IHC-P 1:100-1:200
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EIF1AX
Gene ID: 1964
Uniprot ID: IF1AX_HUMAN
Immunogen Region: 10-144
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 10-144 of human EIF1AX (NP_001403.1).
Immunogen Sequence: KNRRRGKNENESEKRELVFK EDGQEYAQVIKMLGNGRLEA MCFDGVKRLCHIRGKLRKKV WINTSDIILVGLRDYQDNKA DVILKYNADEARSLKAYGEL PEHAKINETDTFGPGDDDEI QFDDIGDDDEDIDDI
Function Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1.
Protein Name Eukaryotic Translation Initiation Factor 1a - X-Chromosomal
Eif-1a X Isoform
Eif1a X Isoform
Eukaryotic Translation Initiation Factor 4c
Eif-4c
Database Links Reactome: R-HSA-156827
Reactome: R-HSA-72649
Reactome: R-HSA-72689
Reactome: R-HSA-72695
Reactome: R-HSA-72702
Reactome: R-HSA-72706
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Eukaryotic Translation Initiation Factor 1a - X-Chromosomal antibody
Anti-Eif-1a X Isoform antibody
Anti-Eif1a X Isoform antibody
Anti-Eukaryotic Translation Initiation Factor 4c antibody
Anti-Eif-4c antibody
Anti-EIF1AX antibody
Anti-EIF1A antibody
Anti-EIF4C antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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