產(chǎn)品詳情
簡(jiǎn)單介紹:
Anti-EHMT1 antibody [1B7B4] (STJ98015)
詳情介紹:
Host: | Mouse |
Applications: | WB/ELISA |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Mouse monoclonal antibody anti-Histone-lysine N-methyltransferase EHMT1 is suitable for use in Western Blot and ELISA research applications. |
Clonality: | Monoclonal |
Clone ID: | 1B7B4 |
Conjugation: | Unconjugated |
Isotype: | IgG1 |
Formulation: | Liquid in PBS containing 0.03% Sodium Azide. |
Purification: | Affinity purification |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-1:2000 ELISA 1:10000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | EHMT1 |
Gene ID: | 79813 |
Uniprot ID: | EHMT1_HUMAN |
Specificity: | EHMT1 Monoclonal Antibody detects endogenous levels of EHMT1 protein. |
Immunogen: | Purified recombinant fragment of EHMT1 expressed in E. Coli. |
Function | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B. |
Protein Name | Histone-Lysine N-Methyltransferase Ehmt1 Euchromatic Histone-Lysine N-Methyltransferase 1 Eu-Hmtase1 G9a-Like Protein 1 Glp Glp1 Histone H3-K9 Methyltransferase 5 H3-K9-Hmtase 5 Lysine N-Methyltransferase 1d |
Database Links | Reactome: R-HSA-2559582 Reactome: R-HSA-3214841 Reactome: R-HSA-6804760 Reactome: R-HSA-8853884 Reactome: R-HSA-8953750 |
Cellular Localisation | Nucleus Chromosome Associates With Euchromatic Regions |
Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase Ehmt1 antibody Anti-Euchromatic Histone-Lysine N-Methyltransferase 1 antibody Anti-Eu-Hmtase1 antibody Anti-G9a-Like Protein 1 antibody Anti-Glp antibody Anti-Glp1 antibody Anti-Histone H3-K9 Methyltransferase 5 antibody Anti-H3-K9-Hmtase 5 antibody Anti-Lysine N-Methyltransferase 1d antibody Anti-EHMT1 antibody Anti-EUHMTASE1 antibody Anti-GLP antibody Anti-KIAA1876 antibody Anti-KMT1D antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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