產(chǎn)品詳情
簡單介紹：
Anti-EHMT1 antibody (1-260) (STJ110811)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-EHMT1 (1-260) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EHMT1 |
| Gene ID: | 79813 |
| Uniprot ID: | EHMT1_HUMAN |
| Immunogen Region: | 1-260 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human EHMT1 (NP_079033.4). |
| Immunogen Sequence: | MAAADAEAVPARGEPQQDCC VKTELLGEETPMAADEGSAE KQAGEAHMAADGETNGSCEN SDASSHANAAKHTQDSARVN PQDGTNTLTRIAENGVSERD SEAAKQNHVTADDFVQTSVI GSNGYILNKPALQAQPLRTT STLASSLPGHAAKTLPGGAG KGRTPSAFPQTPAAPPATLG EGSADTEDRKLPAPGADVKV HRARKTMPKSVVGLHAASKD PREVREARDHKEPKEEINK |
| Tissue Specificity | Widely expressed. |
| Function | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B. |
| Protein Name | Histone-Lysine N-Methyltransferase Ehmt1 Euchromatic Histone-Lysine N-Methyltransferase 1 Eu-Hmtase1 G9a-Like Protein 1 Glp Glp1 Histone H3-K9 Methyltransferase 5 H3-K9-Hmtase 5 Lysine N-Methyltransferase 1d |
| Database Links | Reactome: R-HSA-2559582 Reactome: R-HSA-3214841 Reactome: R-HSA-6804760 Reactome: R-HSA-8853884 Reactome: R-HSA-8953750 |
| Cellular Localisation | Nucleus Chromosome Associates With Euchromatic Regions |
| Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase Ehmt1 antibody Anti-Euchromatic Histone-Lysine N-Methyltransferase 1 antibody Anti-Eu-Hmtase1 antibody Anti-G9a-Like Protein 1 antibody Anti-Glp antibody Anti-Glp1 antibody Anti-Histone H3-K9 Methyltransferase 5 antibody Anti-H3-K9-Hmtase 5 antibody Anti-Lysine N-Methyltransferase 1d antibody Anti-EHMT1 antibody Anti-EUHMTASE1 antibody Anti-GLP antibody Anti-KIAA1876 antibody Anti-KMT1D antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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