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  • 產(chǎn)品名稱(chēng)：Anti-EGR2 antibody (200-300) (STJ117247)

  • 產(chǎn)品型號(hào)：STJ117247
  • 產(chǎn)品廠(chǎng)商：ST john's laboratory
  • 產(chǎn)品文檔：
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Anti-EGR2 antibody (200-300) (STJ117247)
詳情介紹：
Host: Rabbit
Applications: WB
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-EGR2 (200-300) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EGR2
Gene ID: 1959
Uniprot ID: EGR2_HUMAN
Immunogen Region: 200-300
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 200-300 of human EGR2 (NP_000390.2).
Immunogen Sequence: LAYPPPPSYPSPKPATDPGL FPMIPDYPGFFPSQCQRDLH GTAGPDRKPFPCPLDTLRVP PPLTPLSTIRNFTLGGPSAG VTGPGASGGSEGPRLPGSSS A
Post Translational Modifications Ubiquitinated by WWP2 leading to proteasomal degradation. Acetylated at Lys-247. May be deacetylated by HDAC6, HDAC10 or SIRT1.
Function Sequence-specific DNA-binding transcription factor. Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin. Binds to two EGR2-consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation. Binds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2. Regulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres. Promotes the expression of HOXB3 in the rhombomere r5 in the hindbrain. Regulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells. Involved in the development of the jaw openener musculature, probably by playing a role in its innervation through trigeminal motor neurons. May play a role in adipogenesis, possibly by regulating the expression of CEBPB. E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity.
Protein Name E3 Sumo-Protein Ligase Egr2
At591
E3 Sumo-Protein Transferase Erg2
Early Growth Response Protein 2
Egr-2
Zinc Finger Protein Krox-20
Database Links Reactome: R-HSA-381340
Reactome: R-HSA-5617472
Reactome: R-HSA-9031628
Reactome: R-HSA-9619665
Cellular Localisation Nucleus
Alternative Antibody Names Anti-E3 Sumo-Protein Ligase Egr2 antibody
Anti-At591 antibody
Anti-E3 Sumo-Protein Transferase Erg2 antibody
Anti-Early Growth Response Protein 2 antibody
Anti-Egr-2 antibody
Anti-Zinc Finger Protein Krox-20 antibody
Anti-EGR2 antibody
Anti-KROX20 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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