產(chǎn)品詳情
簡單介紹：
Anti-EGR1 antibody (1-250) (STJ29407)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-EGR1 (1-250) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EGR1 |
| Gene ID: | 1958 |
| Uniprot ID: | EGR1_HUMAN |
| Immunogen Region: | 1-250 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human EGR1 (NP_001955.1). |
| Immunogen Sequence: | MAAAKAEMQLMSPLQISDPF GSFPHSPTMDNYPKLEEMML LSNGAPQFLGAAGAPEGSGS NSSSSSSGGGGGGGGGSNSS SSSSTFNPQADTGEQPYEHL TAESFPDISLNNEKVLVETS YPSQTTRLPPITYTGRFSLE PAPNSGNTLWPEPLFSLVSG LVSMTNPPASSSSAPSPAAS SASASQSPPLSCAVPSNDSS PIYSAAPTFPTPNTDIFPEP QSQAFPGSAGTALQYPPPA |
| Tissue Specificity | Detected in neutrophils (at protein level). |
| Function | Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia.regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary. Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN). |
| Protein Name | Early Growth Response Protein 1 Egr-1 At225 Nerve Growth Factor-Induced Protein A Ngfi-A Transcription Factor Etr103 Transcription Factor Zif268 Zinc Finger Protein 225 Zinc Finger Protein Krox-24 |
| Database Links | Reactome: R-HSA-8943724 Reactome: R-HSA-9031628 Reactome: R-HSA-909733 |
| Cellular Localisation | Nucleus Cytoplasm |
| Alternative Antibody Names | Anti-Early Growth Response Protein 1 antibody Anti-Egr-1 antibody Anti-At225 antibody Anti-Nerve Growth Factor-Induced Protein A antibody Anti-Ngfi-A antibody Anti-Transcription Factor Etr103 antibody Anti-Transcription Factor Zif268 antibody Anti-Zinc Finger Protein 225 antibody Anti-Zinc Finger Protein Krox-24 antibody Anti-EGR1 antibody Anti-KROX24 antibody Anti-ZNF225 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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