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產(chǎn)品名稱：Anti-EFNB1 antibody (259-346) (STJ116773)
產(chǎn)品型號：STJ116773
產(chǎn)品廠商：ST john's laboratory
產(chǎn)品文檔：

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簡單介紹：

Anti-EFNB1 antibody (259-346) (STJ116773)

詳情介紹：

Host:	Rabbit
Applications:	WB
Reactivity:	Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-EFNB1 (259-346) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	EFNB1
Gene ID:	1947
Uniprot ID:	EFNB1_HUMAN
Immunogen Region:	259-346
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 259-346 of human EFNB1 (NP_004420.1).
Immunogen Sequence:	TVLLLKLRKRHRKHTQQRAA ALSLSTLASPKGGSGTAGTE PSDIIIPLRTTENNYCPHYE KVSGDYGHPVYIVQEMPPQS PANIYYKV

Tissue Specificity	Widely expressed. Detected in both neuronal and non-neuronal tissues. Seems to have particularly strong expression in retina, sciatic nerve, heart and spinal cord.
Post Translational Modifications	Inducible phosphorylation of tyrosine residues in the cytoplasmic domain. Proteolytically processed. The ectodomain is cleaved, probably by a metalloprotease, to produce a membrane-tethered C-terminal fragment. This fragment is then further processed by the gamma-secretase complex to yield a soluble intracellular domain peptide which can translocate to the nucleus. The intracellular domain peptide is highly labile suggesting that it is targeted for degradation by the proteasome.
Function	Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells. Shows high affinity for the receptor tyrosine kinase EPHB1/ELK. Can also bind EPHB2 and EPHB3. Binds to, and induces collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons.
Protein Name	Ephrin-B1 Efl-3 Elk Ligand Elk-L Eph-Related Receptor Tyrosine Kinase Ligand 2 Lerk-2 Cleaved Into - Ephrin-B1 C-Terminal Fragment Ephrin-B1 Ctf - Ephrin-B1 Intracellular Domain Ephrin-B1 Icd
Database Links	Reactome: R-HSA-2682334 Reactome: R-HSA-3928662 Reactome: R-HSA-3928664 Reactome: R-HSA-3928665
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Membrane Raft May Recruit Grip1 And Grip2 To Membrane Raft Domains Ephrin-B1 C-Terminal Fragment: Cell Membrane Ephrin-B1 Intracellular Domain: Nucleus Colocalizes With Zhx2 In The Nucleus
Alternative Antibody Names	Anti-Ephrin-B1 antibody Anti-Efl-3 antibody Anti-Elk Ligand antibody Anti-Elk-L antibody Anti-Eph-Related Receptor Tyrosine Kinase Ligand 2 antibody Anti-Lerk-2 Cleaved Into - Ephrin-B1 C-Terminal Fragment antibody Anti-Ephrin-B1 Ctf - Ephrin-B1 Intracellular Domain antibody Anti-Ephrin-B1 Icd antibody Anti-EFNB1 antibody Anti-EFL3 antibody Anti-EPLG2 antibody Anti-LERK2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產(chǎn)品名稱：Anti-EFNB1 antibody (259-346) (STJ116773)