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產品詳情

  • 產品名稱：Mouse MIP3a (Macrophage Inflammatory Protein 3 Alpha) Sandwich ELISA Kit (STJE0010614)

  • 產品型號：STJE0010614
  • 產品廠商：ST john's laboratory
  • 產品文檔：
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簡單介紹：
Mouse MIP3a (Macrophage Inflammatory Protein 3 Alpha) Sandwich ELISA Kit (STJE0010614)
詳情介紹：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 27pg/mL
Detection Limit: 78.1-5000pg/mL
Short Description: This MIP3a Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Ccl20
Gene ID: 20297
Uniprot ID: CCL20_MOUSE
Sample Type: serum, plasma or other biological fluids.
Tissue Specificity Thymic medulla (at protein level). Prominently expressed in the small intestine, colon and appendix. Also found in thymus, spleen, lymph node and lung. The long form might be dominant in intestinal, and the short form in lymphoid tissues. Expressed by IL17 producing helper T-cells (Th17).
Post Translational Modifications
Function Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and autoimmune diseases. CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Involved in the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells. Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells.
Protein Name C-C Motif Chemokine 20
Beta-Chemokine Exodus-1
Cc Chemokine Larc
Cc Chemokine St38
Liver And Activation-Regulated Chemokine
Macrophage Inflammatory Protein 3 Alpha
Mip-3-Alpha
Small-Inducible Cytokine A20
Database Links Reactome: R-MMU-380108
Reactome: -MMU-418594
Cellular Localisation Secreted
Alternative ELISA Names C-C Motif Chemokine 20 ELISA kit
Beta-Chemokine Exodus-1 ELISA kit
Cc Chemokine Larc ELISA kit
Cc Chemokine St38 ELISA kit
Liver And Activation-Regulated Chemokine ELISA kit
Macrophage Inflammatory Protein 3 Alpha ELISA kit
Mip-3-Alpha ELISA kit
Small-Inducible Cytokine A20 ELISA kit
Ccl20 ELISA kit
Larc ELISA kit
Scya20 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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