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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-ADAM15 antibody (50-130 aa) (STJ192358)

  • 產(chǎn)品型號：STJ192358
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
Anti-ADAM15 antibody (50-130 aa) (STJ192358)
詳情介紹：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Disintegrin and metalloproteinase domain-containing protein 15 (50-130 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ADAM15
Gene ID: 8751
Uniprot ID: ADA15_HUMAN
Immunogen Region: 50-130 aa
Specificity: ADA15 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from the human protein at the amino acid range 50-130
Post Translational Modifications The precursor is cleaved by a furin endopeptidase. Phosphorylation increases association with PTKs.
Function Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.
Protein Name Disintegrin And Metalloproteinase Domain-Containing Protein 15
Adam 15
Metalloprotease Rgd Disintegrin Protein
Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein 15
Mdc-15
Metargidin
Database Links Reactome: R-HSA-1474228
Reactome: R-HSA-8941237
Cellular Localisation Endomembrane System
Single-Pass Type I Membrane Protein
Cell Junction
Adherens Junction
Cell Projection
Cilium
Flagellum
Cytoplasmic Vesicle
Secretory Vesicle
Acrosome
The Majority Of The Protein Is Localized In A Perinuclear Compartment Which May Correspond To The Trans-Golgi Network Or The Late Endosome
The Pro-Protein Is The Major Detectable Form On The Cell Surface
Whereas The Majority Of The Protein In The Cell Is Processed
Alternative Antibody Names Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 15 antibody
Anti-Adam 15 antibody
Anti-Metalloprotease Rgd Disintegrin Protein antibody
Anti-Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein 15 antibody
Anti-Mdc-15 antibody
Anti-Metargidin antibody
Anti-ADAM15 antibody
Anti-MDC15 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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