產(chǎn)品詳情
簡單介紹：
Anti-ADAM10 antibody (214-672) (STJ11105576)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/IF/FC |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Disintegrin And Metalloproteinase Domain-Containing Protein 10 (214-672) is suitable for use in Western Blot, Immunofluorescence and Flow Cytometry research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:1000-1:5000 IF/ICC 1:50-1:200 FC 1:500-1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ADAM10 |
| Gene ID: | 102 |
| Uniprot ID: | ADA10_HUMAN |
| Immunogen Region: | 214-672 |
| Immunogen: | Recombinant Protein corresponding to a sequence within amino acids 214-672 of human ADAM10 (NP_001101.1). |
| Immunogen Sequence: | TTSAEKNTCQLYIQTDHLFF KYYGTREAVIAQISSHVKAI DTIYQTTDFSGIRNISFMVK RIRINTTADEKDPTNPFRFP NIGVEKFLELNSEQNHDDYC LAYVFTDRDFDDGVLGLAWV GAPSGSSGGICEKSKLYSDG KKKSLNTGIITVQNYGSHVP PKVSHITFAHEVGHNFGSPH DSGTECTPGESKNLGQKENG NYIMYARATSGDKLNNNKFS LCSIRNISQVLEKKRNNCF |
| Tissue Specificity | Expressed in the brain (at protein level). Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver. |
| Post Translational Modifications | The precursor is cleaved by furin and PCSK7. |
| Function | Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3. Mediates the proteolytic cleavage of IL6R and IL11RA, leading to the release of secreted forms of IL6R and IL11RA. Enhances the cleavage of CHL1 by BACE1. Cleaves NRCAM. Cleaves TREM2, resulting in shedding of the TREM2 ectodomain. Involved in the development and maturation of glomerular and coronary vasculature. During development of the cochlear organ of Corti, promotes pillar cell separation by forming a ternary complex with CADH1 and EPHA4 and cleaving CADH1 at adherens junctions. May regulate the EFNA5-EPHA3 signaling. (Microbial infection) Promotes the cytotoxic activity of S.aureus hly by binding to the toxin at zonula adherens and promoting formation of toxin pores. |
| Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 10 Adam 10 Cdw156 Kuzbanian Protein Homolog Mammalian Disintegrin-Metalloprotease Cd Antigen Cd156c |
| Database Links | Reactome: R-HSA-1442490 Reactome: R-HSA-1474228 Reactome: R-HSA-177929 Reactome: R-HSA-2122948 Reactome: R-HSA-2644606 Reactome: R-HSA-2660826 Reactome: R-HSA-2691232 Reactome: R-HSA-2894862 Reactome: R-HSA-2979096 Reactome: R-HSA-381426 Reactome: R-HSA-3928665 Reactome: R-HSA-6798695 Reactome: R-HSA-8957275 Reactome: R-HSA-9013507 Reactome: R-HSA-9013700 Reactome: R-HSA-977225 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Golgi Apparatus Membrane Cytoplasmic Vesicle Clathrin-Coated Vesicle Cell Projection Axon Dendrite Cell Junction Adherens Junction Cytoplasm Is Localized In The Plasma Membrane But Is Also Expressed In The Golgi Apparatus And In Clathrin-Coated Vesicles Derived Likely From The Golgi During Long Term Depression It Is Recruited To The Cell Membrane By Dlg1 The Immature Form Is Mainly Located Near Cytoplasmic Fibrillar Structures While The Mature Form Is Predominantly Located At Zonula Adherens And The Cell Membrane The Localization And Clustering Of Mature Adam10 To Zonula Adherens Is Regulated By Afdn Tspan33 Plekha7 And Pdzd11 |
| Alternative Antibody Names | Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 10 antibody Anti-Adam 10 antibody Anti-Cdw156 antibody Anti-Kuzbanian Protein Homolog antibody Anti-Mammalian Disintegrin-Metalloprotease antibody Anti-Cd Antigen Cd156c antibody Anti-ADAM10 antibody Anti-KUZ antibody Anti-MADM antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
相關(guān)信息
![Anti-14-3-3 beta/Theta antibody (1-100) [S1MR] (STJ11103651)](http://y1.yzimgs.com/uploads/465546/2024520-20551366.png?imageView2/2/w/200/h/200)
- 細胞培養(yǎng)玄學(xué)-MRC-5細胞 2025-01-07
- Ocean NanoTech定制的詳細步驟 2021-10-31
- click chemistry tools數(shù)據(jù)結(jié)果比... 2021-10-31
- Abbiotec代理的產(chǎn)品得到重復(fù)驗證2020 2021-10-31
- LaysanBio代理商相關(guān)文獻資料2020 2021-10-31
- zyagen Laboratories代理的產(chǎn)品得到... 2021-06-20
- Toxin Technologies代理商相關(guān)文獻資... 2021-03-14
- 熱烈祝賀玉博生物正式代理biocolor公司試劑產(chǎn)品... 2021-03-14
- 熱烈祝賀玉博生物正式代理cytognos公司試劑產(chǎn)品... 2021-03-14
- Gelest代理的產(chǎn)品得到重復(fù)驗證2020 2021-03-14
