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產(chǎn)品名稱：human FGF-23/Fibroblast growth factor 23 protein (Recombinant) (C-His) (STJP001918)
產(chǎn)品型號(hào)：STJP001918
產(chǎn)品廠商：ST john's laboratory
產(chǎn)品文檔：

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human FGF-23/Fibroblast growth factor 23 protein (Recombinant) (C-His) (STJP001918)

詳情介紹：

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-human FGF-23/Fibroblast growth factor 23-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of 20mM MOPS, 150mM NaCl, 5mM EDTA, 2mM DTT, pH 7.4
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FGF23
Gene ID:	8074
Uniprot ID:	FGF23_HUMAN
Immunogen Region:	Tyr25-Ile251
Immunogen:	Recombinant human FGF-23/Fibroblast growth factor 23 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Tyr25-Ile251) of human FGF-23/Fibroblast growth factor 23 (Accession #NP_065689.1) fused witha

Post Translational Modifications	Following secretion this protein is inactivated by cleavage into a N-terminal fragment and a C-terminal fragment. The processing is effected by proprotein convertases. O-glycosylated at Thr-171 and Thr-178 by GALNT3 and glycosylation of Thr-178 requires previous glycosylation at Thr171. Glycosylation is necessary for secretion.it blocks processing by proprotein convertases when the O-glycan is alpha 2,6-sialylated. Competition between proprotein convertase cleavage and block of cleavage by O-glycosylation determines the level of secreted active FGF23. Phosphorylation at Ser-180 mediated by FAM20C slows down glycosylation at Thr-178 notably.
Function	Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Up-regulates EGR1 expression in the presence of KL. Acts directly on the parathyroid to decrease PTH secretion. Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization.
Protein Name	Fibroblast Growth Factor 23 Fgf-23 Phosphatonin Tumor-Derived Hypophosphatemia-Inducing Factor Cleaved Into - Fibroblast Growth Factor 23 N-Terminal Peptide - Fibroblast Growth Factor 23 C-Terminal Peptide
Database Links	Reactome: R-HSA-109704 Reactome: R-HSA-1257604 Reactome: R-HSA-1839122 Reactome: R-HSA-1839130 Reactome: R-HSA-190322 Reactome: R-HSA-190372 Reactome: R-HSA-190373 Reactome: R-HSA-190374 Reactome: R-HSA-190375 Reactome: R-HSA-2033519 Reactome: R-HSA-2219530 Reactome: R-HSA-381426 Reactome: R-HSA-5654219 Reactome: R-HSA-5654221 Reactome: R-HSA-5654227 Reactome: R-HSA-5654228 Reactome: R-HSA-5654687 Reactome: R-HSA-5654688 Reactome: R-HSA-5654689 Reactome: R-HSA-5654693 Reactome: R-HSA-5654695 Reactome: R-HSA-5654699 Reactome: R-HSA-5654700 Reactome: R-HSA-5654704 Reactome: R-HSA-5654706 Reactome: R-HSA-5654710 Reactome: R-HSA-5654712 Reactome: R-HSA-5654719 Reactome: R-HSA-5654720 Reactome: R-HSA-5654726 Reactome: R-HSA-5654727 Reactome: R-HSA-5654732 Reactome: R-HSA-5654733 Reactome: R-HSA-5655253 Reactome: R-HSA-5655302 Reactome: R-HSA-5655332 Reactome: R-HSA-5658623 Reactome: R-HSA-5673001 Reactome: R-HSA-6811558 Reactome: R-HSA-8957275
Cellular Localisation	Secreted Secretion Is Dependent On O-Glycosylation
Alternative Protein Names	Fibroblast Growth Factor 23 protein Fgf-23 protein Phosphatonin protein Tumor-Derived Hypophosphatemia-Inducing Factor Cleaved Into - Fibroblast Growth Factor 23 N-Terminal Peptide - Fibroblast Growth Factor 23 C-Terminal Peptide protein FGF23 protein HYPF protein UNQ3027 protein PRO9828 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產(chǎn)品名稱：human FGF-23/Fibroblast growth factor 23 protein (Recombinant) (C-His) (STJP001918)