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Anti-ADA antibody (250-350) [S6MR] (STJ11102276)

詳情介紹：

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-ADA (250-350) is suitable for use in Western Blot research applications.

Clonality:	Monoclonal
Clone ID:	S6MR
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ADA
Gene ID:	100
Uniprot ID:	ADA_HUMAN
Immunogen Region:	250-350
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 250-350 of human Adenosine Deaminase (ADA) (NP_000013.2).
Immunogen Sequence:	NRLRQENMHFEICPWSSYLT GAWKPDTEHAVIRLKNDQAN YSLNTDDPLIFKSTLDTDYQ MTKRDMGFTEEEFKRLNINA AKSSFLPEDEKRELLDLLYK A

Tissue Specificity	Found in all tissues, occurs in large amounts in T-lymphocytes. Expressed at the time of weaning in gastrointestinal tissues.
Function	Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion. Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion. Enhances CD4+ T-cell differentiation and proliferation. Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change. Stimulates plasminogen activation. Plays a role in male fertility. Plays a protective role in early postimplantation embryonic development.
Protein Name	Adenosine Deaminase Adenosine Aminohydrolase
Database Links	Reactome: R-HSA-74217 Reactome: R-HSA-9734735 Reactome: R-HSA-9755088
Cellular Localisation	Cell Membrane Peripheral Membrane Protein Extracellular Side Cell Junction Cytoplasmic Vesicle Lumen Cytoplasm Lysosome Colocalized With Dpp4 At The Cell Surface
Alternative Antibody Names	Anti-Adenosine Deaminase antibody Anti-Adenosine Aminohydrolase antibody Anti-ADA antibody Anti-ADA1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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