產(chǎn)品詳情
簡單介紹：
Anti-ADA antibody (1-363) (STJ118001)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/IF |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-ADA (1-363) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000 IF/ICC 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ADA |
| Gene ID: | 100 |
| Uniprot ID: | ADA_HUMAN |
| Immunogen Region: | 1-363 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-363 of human Adenosine Deaminase (Adenosine Deaminase (ADA) ) (NP_000013.2). |
| Immunogen Sequence: | MAQTPAFDKPKVELHVHLDG SIKPETILYYGRRRGIALPA NTAEGLLNVIGMDKPLTLPD FLAKFDYYMPAIAGCREAIK RIAYEFVEMKAKEGVVYVEV RYSPHLLANSKVEPIPWNQA EGDLTPDEVVALVGQGLQEG ERDFGVKARSILCCMRHQPN WSPKVVELCKKYQQQTVVAI DLAGDETIPGSSLLPGHVQA YQEAVKSGIHRTVHAGEVGS AEVVKEAVDILKTERLGHG |
| Tissue Specificity | Found in all tissues, occurs in large amounts in T-lymphocytes. Expressed at the time of weaning in gastrointestinal tissues. |
| Function | Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion. Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion. Enhances CD4+ T-cell differentiation and proliferation. Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change. Stimulates plasminogen activation. Plays a role in male fertility. Plays a protective role in early postimplantation embryonic development. |
| Protein Name | Adenosine Deaminase Adenosine Aminohydrolase |
| Database Links | Reactome: R-HSA-74217 Reactome: R-HSA-9734735 Reactome: R-HSA-9755088 |
| Cellular Localisation | Cell Membrane Peripheral Membrane Protein Extracellular Side Cell Junction Cytoplasmic Vesicle Lumen Cytoplasm Lysosome Colocalized With Dpp4 At The Cell Surface |
| Alternative Antibody Names | Anti-Adenosine Deaminase antibody Anti-Adenosine Aminohydrolase antibody Anti-ADA antibody Anti-ADA1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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