產(chǎn)品詳情
簡單介紹：
Anti-ACVRL1 antibody (234-503) (STJ111113)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-ACVRL1 (234-503) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ACVRL1 |
| Gene ID: | 94 |
| Uniprot ID: | ACVL1_HUMAN |
| Immunogen Region: | 234-503 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 234-503 of human ACVRL1 (NP_001070869.1). |
| Immunogen Sequence: | RDEQSWFRETEIYNTVLLRH DNILGFIASDMTSRNSSTQL WLITHYHEHGSLYDFLQRQT LEPHLALRLAVSAACGLAHL HVEIFGTQGKPAIAHRDFKS RNVLVKSNLQCCIADLGLAV MHSQGSDYLDIGNNPRVGTK RYMAPEVLDEQIRTDCFESY KWTDIWAFGLVLWEIARRTI VNGIVEDYRPPFYDVVPNDP SFEDMKKVVCVDQQTPTIPN RLAADPVLSGLAQMMRECW |
| Function | Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. |
| Protein Name | Serine/Threonine-Protein Kinase Receptor R3 Skr3 Activin Receptor-Like Kinase 1 Alk-1 Tgf-B Superfamily Receptor Type I Tsr-I |
| Database Links | Reactome: R-HSA-201451 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Receptor R3 antibody Anti-Skr3 antibody Anti-Activin Receptor-Like Kinase 1 antibody Anti-Alk-1 antibody Anti-Tgf-B Superfamily Receptor Type I antibody Anti-Tsr-I antibody Anti-ACVRL1 antibody Anti-ACVRLK1 antibody Anti-ALK1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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