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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-ACVR1B antibody (24-126) (STJ119153)

  • 產(chǎn)品型號(hào)：STJ119153
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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Anti-ACVR1B antibody (24-126) (STJ119153)
詳情介紹：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ACVR1B (24-126) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ACVR1B
Gene ID: 91
Uniprot ID: ACV1B_HUMAN
Immunogen Region: 24-126
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 24-126 of human ACVR1B (NP_004293.1).
Immunogen Sequence: SGPRGVQALLCACTSCLQAN YTCETDGACMVSIFNLDGME HHVRTCIPKVELVPAGKPFY CLSSEDLRNTHCCYTDYCNR IDLRVPSGHLKEPEHPSMWG PVE
Tissue Specificity Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver.
Post Translational Modifications Autophosphorylated. Phosphorylated by activin receptor type-2 (ACVR2A or ACVR2B) in response to activin-binding at serine and threonine residues in the GS domain. Phosphorylation of ACVR1B by activin receptor type-2 regulates association with SMAD7. Ubiquitinated. Level of ubiquitination is regulated by the SMAD7-SMURF1 complex. Ubiquitinated.
Function Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.
Protein Name Activin Receptor Type-1b
Activin Receptor Type Ib
Actr-Ib
Activin Receptor-Like Kinase 4
Alk-4
Serine/Threonine-Protein Kinase Receptor R2
Skr2
Database Links Reactome: R-HSA-1181150
Reactome: R-HSA-1433617
Reactome: R-HSA-1502540
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Activin Receptor Type-1b antibody
Anti-Activin Receptor Type Ib antibody
Anti-Actr-Ib antibody
Anti-Activin Receptor-Like Kinase 4 antibody
Anti-Alk-4 antibody
Anti-Serine/Threonine-Protein Kinase Receptor R2 antibody
Anti-Skr2 antibody
Anti-ACVR1B antibody
Anti-ACVRLK4 antibody
Anti-ALK4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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