產(chǎn)品詳情
簡單介紹:
Ephrin Receptor A8 Blocking Peptide peptide (STJ504016)
詳情介紹:
Applications: | Immunodepletion/Immunocompetition |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Ephrin Receptor A8 Blocking Peptide is synthetically produced from the sequence and is suitable for use in western blot applications. |
Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Gene Symbol: | EPHA8 |
Gene ID: | 2046 |
Uniprot ID: | EPHA8_HUMAN |
Immunogen: | Synthetic peptide corresponding to unique amino acid sequences on human EphA R8 protein. |
Function | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system also plays a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth. |
Peptide Name | Ephrin Type-A Receptor 8 Eph- And Elk-Related Kinase Eph-Like Kinase 3 Ek3 Hek3 Tyrosine-Protein Kinase Receptor Eek |
Database Links | Reactome: R-HSA-2682334 Reactome: R-HSA-3928663 Reactome: R-HSA-3928665 |
Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Cell Projection Early Endosome Membrane Undergoes Clathrin-Mediated Endocytosis Upon Efna5-Binding And Is Targeted To Early Endosomes |
Alternative Peptide Names | Ephrin Type-A Receptor 8 protein Eph- And Elk-Related Kinase protein Eph-Like Kinase 3 protein Ek3 protein Hek3 protein Tyrosine-Protein Kinase Receptor Eek protein EPHA8 protein EEK protein HEK3 protein KIAA1459 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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