產(chǎn)品詳情
簡(jiǎn)單介紹:
Ephrin Receptor A3 Blocking Peptide peptide (STJ504011)
詳情介紹:
Applications: | Immunodepletion/Immunocompetition |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Ephrin Receptor A3 Blocking Peptide is synthetically produced from the 900-980 sequence and is suitable for use in western blot applications. |
Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Gene Symbol: | EPHA3 |
Gene ID: | 2042 |
Uniprot ID: | EPHA3_HUMAN |
Immunogen Region: | 900-980 |
Immunogen: | Synthetic peptide taken within amino acid region 900-980 on human EPHA3 protein |
Tissue Specificity | Widely expressed. Highest level in placenta. |
Post Translational Modifications | Autophosphorylates upon activation by EFNA5. Phosphorylation on Tyr-602 mediates interaction with NCK1. Dephosphorylated by PTPN1. |
Function | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. |
Peptide Name | Ephrin Type-A Receptor 3 Eph-Like Kinase 4 Ek4 Hek4 Hek Human Embryo Kinase Tyrosine-Protein Kinase Tyro4 Tyrosine-Protein Kinase Receptor Etk1 Eph-Like Tyrosine Kinase 1 |
Database Links | Reactome: R-HSA-2682334 Reactome: R-HSA-3928663 Reactome: R-HSA-3928665 |
Cellular Localisation | Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Isoform 2: Secreted |
Alternative Peptide Names | Ephrin Type-A Receptor 3 protein Eph-Like Kinase 4 protein Ek4 protein Hek4 protein Hek protein Human Embryo Kinase protein Tyrosine-Protein Kinase Tyro4 protein Tyrosine-Protein Kinase Receptor Etk1 protein Eph-Like Tyrosine Kinase 1 protein EPHA3 protein ETK protein ETK1 protein HEK protein TYRO4 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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