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產(chǎn)品詳情

  • 產(chǎn)品名稱：Ephrin Receptor A1 Blocking Peptide peptide (STJ505303)

  • 產(chǎn)品型號：STJ505303-250
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
Ephrin Receptor A1 Blocking Peptide peptide (STJ505303)
詳情介紹：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Ephrin Receptor A1 Blocking Peptide is synthetically produced from the 55-605 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: EPHA1
Gene ID: 2041
Uniprot ID: EPHA1_HUMAN
Immunogen Region: 55-605
Immunogen: Synthetic peptide taken within amino acid region 55-605 on human Ephrin type-A receptor 1.
Tissue Specificity Overexpressed in several carcinomas.
Post Translational Modifications Phosphorylated. Autophosphorylation is stimulated by its ligand EFNA1. Ubiquitinated.
Function Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Also plays a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
Peptide Name Ephrin Type-A Receptor 1
Hepha1
Eph Tyrosine Kinase
Eph Tyrosine Kinase 1
Erythropoietin-Producing Hepatoma Receptor
Tyrosine-Protein Kinase Receptor Eph
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-2892247
Reactome: R-HSA-3928663
Reactome: R-HSA-3928665
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Peptide Names Ephrin Type-A Receptor 1 protein
Hepha1 protein
Eph Tyrosine Kinase protein
Eph Tyrosine Kinase 1 protein
Erythropoietin-Producing Hepatoma Receptor protein
Tyrosine-Protein Kinase Receptor Eph protein
EPHA1 protein
EPH protein
EPHT protein
EPHT1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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