產(chǎn)品詳情
簡(jiǎn)單介紹：
Human Fc epsilon RI alpha protein (Recombinant) (C-His) (STJP001014)
詳情介紹：
| Host: | HEK293 cells |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Recombinant-Human Fc epsilon RI alpha-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
| Formulation: | Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation. |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized FITC anti-human Fc Epsilon RI Alpha Antibody at 1 Mu g/mL (25 Mu L/well) can bind Human Fc epsilon RI alpha with a linear range of 0.46-3.15 ng/mL. |
| Gene Symbol: | FCER1A |
| Gene ID: | 2205 |
| Uniprot ID: | FCERA_HUMAN |
| Immunogen Region: | Val26-Gln205 |
| Immunogen: | Recombinant Human Fc epsilon RI alpha Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Val26-Gln205) of human Fc epsilon RI alpha (Accession #NP_001992) fused with a 6×His tag at the C-terminus. |
| Tissue Specificity | Expressed in eosinophils. |
| Function | High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation. On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes. Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions. |
| Protein Name | High Affinity Immunoglobulin Epsilon Receptor Subunit Alpha Fc-Epsilon Ri-Alpha Fceri Ige Fc Receptor Subunit Alpha |
| Database Links | Reactome: R-HSA-2454202 Reactome: R-HSA-2730905 Reactome: R-HSA-2871796 Reactome: R-HSA-2871809 Reactome: R-HSA-2871837 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Protein Names | High Affinity Immunoglobulin Epsilon Receptor Subunit Alpha protein Fc-Epsilon Ri-Alpha protein Fceri protein Ige Fc Receptor Subunit Alpha protein FCER1A protein FCE1A protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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