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產(chǎn)品詳情

  • 產(chǎn)品名稱：Human EphB4/HTK protein (Recombinant) (C-hFc & His) (STJP002730)

  • 產(chǎn)品型號：STJP002730
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
Human EphB4/HTK protein (Recombinant) (C-hFc & His) (STJP002730)
詳情介紹：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human EphB4/HTK-C-hFc & His protein was developed from hek293 cells and has a target region of C-hFc & His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human EFNB2 at 0.5 Mu g/mL (100 Mu L/well) can bind Human EPHB4 with a linear range of 6-400 pg/mL.
Gene Symbol: EPHB4
Gene ID: 2050
Uniprot ID: EPHB4_HUMAN
Immunogen Region: Met 1-Ala 539
Immunogen: Recombinant Human EphB4/HTK Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met 1-Ala 539) of human EphB4/HTK (Accession #NP_004435.3) fused with a Fc, 6×His tag at the C-terminus.
Post Translational Modifications Phosphorylated.autophosphorylation is stimulated by EFNB2.
Function Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells.
Protein Name Ephrin Type-B Receptor 4
Hepatoma Transmembrane Kinase
Tyrosine-Protein Kinase Tyro11
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-3928662
Reactome: R-HSA-3928664
Reactome: R-HSA-3928665
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Ephrin Type-B Receptor 4 protein
Hepatoma Transmembrane Kinase protein
Tyrosine-Protein Kinase Tyro11 protein
EPHB4 protein
HTK protein
MYK1 protein
TYRO11 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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