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產(chǎn)品詳情

  • 產(chǎn)品名稱：Human DC-SIGN/CD209 protein (Recombinant) (C-His) (STJP001484)

  • 產(chǎn)品型號：STJP001484
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
Human DC-SIGN/CD209 protein (Recombinant) (C-His) (STJP001484)
詳情介紹：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human DC-SIGN/CD209-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Immunoreactivity: Measured by the ability of the immobilized protein to support the adhesion of ICAM-3 expressing CHO Chinese hamster ovary cells. When 5 x 104 cells/well are added to Recombinant Human DCSIGN/CD209 Protein coated plates (5 Mu g/mL with 100 Mu L/well)
Gene Symbol: CD209
Gene ID: 30835
Uniprot ID: CD209_HUMAN
Immunogen: Recombinant Human DC-SIGN/CD209 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln59-Ala404) of human CD209/DC-SIGN (Accession #NP_066978.1) fused with a 6×His tag at the C-terminus.
Function Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells. (Microbial infection) Acts as an attachment receptor for HIV-1 and HIV-2. (Microbial infection) Acts as an attachment receptor for Ebolavirus. (Microbial infection) Acts as an attachment receptor for Cytomegalovirus. (Microbial infection) Acts as an attachment receptor for HCV. (Microbial infection) Acts as an attachment receptor for Dengue virus. (Microbial infection) Acts as an attachment receptor for Measles virus. (Microbial infection) Acts as an attachment receptor for Herpes simplex virus 1. (Microbial infection) Acts as an attachment receptor for Influenzavirus A. (Microbial infection) Acts as an attachment receptor for SARS-CoV. (Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus. (Microbial infection) Acts as an attachment receptor for Lassa virus. Acts as an attachment receptor for Marburg virusn. (Microbial infection) Acts as an attachment receptor for Respiratory syncytial virus. (Microbial infection) Acts as an attachment receptor for Rift valley fever virus and uukuniemi virus. (Microbial infection) Acts as an attachment receptor for West-nile virus. (Microbial infection) Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of bacterial pathogen antigens, including Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA. Recognition of M.tuberculosis by dendritic cells occurs partially via this molecule.
Protein Name Cd209 Antigen
C-Type Lectin Domain Family 4 Member L
Dendritic Cell-Specific Icam-3-Grabbing Non-Integrin 1
Dc-Sign
Dc-Sign1
Cd Antigen Cd209
Database Links Reactome: R-HSA-5621575
Reactome: R-HSA-8851680
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type Ii Membrane Protein
Isoform 2: Cell Membrane
Isoform 3: Cell Membrane
Isoform 4: Cell Membrane
Isoform 5: Cell Membrane
Isoform 6: Secreted
Isoform 7: Secreted
Isoform 8: Secreted
Isoform 9: Secreted
Isoform 10: Secreted
Isoform 11: Secreted
Isoform 12: Secreted
Alternative Protein Names Cd209 Antigen protein
C-Type Lectin Domain Family 4 Member L protein
Dendritic Cell-Specific Icam-3-Grabbing Non-Integrin 1 protein
Dc-Sign protein
Dc-Sign1 protein
Cd Antigen Cd209 protein
CD209 protein
CLEC4L protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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