產(chǎn)品詳情
簡單介紹：
Anti-ACLY antibody (1000-1101) [S9MR] (STJ11101939)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/IF/IP |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit monoclonal antibody anti-ACLY (1000-1101) is suitable for use in Western Blot, Immunofluorescence and Immunoprecipitation research applications. |
| Clonality: | Monoclonal |
| Clone ID: | S9MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 IF/ICC 1:50-1:200 IP 1:500-1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ACLY |
| Gene ID: | 47 |
| Uniprot ID: | ACLY_HUMAN |
| Immunogen Region: | 1000-1101 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1000-1101 of human ACLY (P53396). |
| Immunogen Sequence: | ATPLLDYALEVEKITTSKKP NLILNVDGLIGVAFVDMLRN CGSFTREEADEYIDIGALNG IFVLGRSMGFIGHYLDQKRL KQGLYRHPWDDISYVLPEHM SM |
| Post Translational Modifications | Phosphorylated by PKA and GSK3 in a sequential manner.phosphorylation results in activation of its activity. Phosphorylation on Thr-447 and Ser-451 depends on the phosphorylation state of Ser-455. Phosphorylation on Ser-455 is decreased by prior phosphorylation on the other 2 residues. ISGylated. Acetylated at Lys-540, Lys-546 and Lys-554 by KAT2B/PCAF. Acetylation is promoted by glucose and stabilizes the protein, probably by preventing ubiquitination at the same sites. Acetylation promotes de novo lipid synthesis. Deacetylated by SIRT2. Ubiquitinated at Lys-540, Lys-546 and Lys-554 by the BCR(KLHL25) E3 ubiquitin ligase complex and UBR4, leading to its degradation. Ubiquitination is probably inhibited by acetylation at same site. BCR(KLHL25)-mediated degradation of ACLY promotes fatty acid oxidation and is required for differentiation of inducible regulatory T (iTreg) cells. |
| Function | Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. |
| Protein Name | Atp-Citrate Synthase Atp-Citrate Pro-S--Lyase Acl Citrate Cleavage Enzyme |
| Database Links | Reactome: R-HSA-163765 Reactome: R-HSA-6798695 Reactome: R-HSA-75105 |
| Cellular Localisation | Cytoplasm Cytosol |
| Alternative Antibody Names | Anti-Atp-Citrate Synthase antibody Anti-Atp-Citrate antibody Anti-Pro-S--Lyase antibody Anti-Acl antibody Anti-Citrate Cleavage Enzyme antibody Anti-ACLY antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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