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產(chǎn)品詳情

  • 產(chǎn)品名稱：CX3CL1 Blocking Peptide for STJ500636 peptide (STJ505484)

  • 產(chǎn)品型號：STJ505484-250
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
CX3CL1 Blocking Peptide for STJ500636 peptide (STJ505484)
詳情介紹：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: CX3CL1 Blocking Peptide for STJ500636 is synthetically produced from the 350-395 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Cx3cl1
Gene ID: 20312
Uniprot ID: X3CL1_MOUSE
Immunogen Region: 350-395
Specificity: This blocking peptide is recommended for use in combination with CX3CL1 antibody, STJ500636
Immunogen: Synthetic peptide taken within amino acid reigon 350-395 on mouse Fractalkine protein.
Tissue Specificity Highest levels in brain. Lower levels in kidney, heart and lung. Also found in skeletal muscle and testis. Highly expressed in lesional smooth muscle cells, but not macrophages. Low levels of ABCD-3 mRNA were also found in anti-CD40-stimulated splenic B-cells, but not in resting B-cells. Also expressed in dendritic cells.
Post Translational Modifications A soluble short 80 kDa form may be released by proteolytic cleavage from the long membrane-anchored form.
Function Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1. The CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. Regulates leukocyte adhesion and migration processes at the endothelium. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1. Processed fractalkine: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. Fractalkine: The membrane-bound form promotes adhesion of those leukocytes to endothelial cells.
Peptide Name Fractalkine
Fk
Abcd-3
C-X3-C Motif Chemokine 1
Cx3c Membrane-Anchored Chemokine
Neurotactin
Small-Inducible Cytokine D1 Cleaved Into - Processed Fractalkine
Database Links Reactome: R-MMU-380108
Reactome: -MMU-418594
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Processed Fractalkine: Secreted
Alternative Peptide Names Fractalkine protein
Fk protein
Abcd-3 protein
C-X3-C Motif Chemokine 1 protein
Cx3c Membrane-Anchored Chemokine protein
Neurotactin protein
Small-Inducible Cytokine D1 Cleaved Into - Processed Fractalkine protein
Cx3cl1 protein
Cx3c protein
Fkn protein
Scyd1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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