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Human CEACAM3/CD66d protein (Recombinant) (C-His) (STJP000907)

詳情介紹：

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human CEACAM3/CD66d-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity:	Measured by its binding ability in a functional ELISA. Immobilized Human CEACAM3 at 1 Mu g/mL (100 Mu L/well) can bind CEACAM3 Mouse mAb with a linear range of 0.1-2.7 ng/mL.

Gene Symbol:	CEACAM3
Gene ID:	1084
Uniprot ID:	CEAM3_HUMAN
Immunogen:	Recombinant Human CEACAM3/CD66d Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Gly155) of human CEACAM3/CD66d (Accession #NP_001806.2) fused with a 6×His tag at the C-terminus.

Tissue Specificity	CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney.
Post Translational Modifications	Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to be detected.
Function	Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.
Protein Name	Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3 Carcinoembryonic Antigen Cgm1 Cd Antigen Cd66d
Database Links	Reactome: R-HSA-202733 Reactome: R-HSA-6798695
Cellular Localisation	Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3 protein Carcinoembryonic Antigen Cgm1 protein Cd Antigen Cd66d protein CEACAM3 protein CD66D protein CGM1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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