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產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：Human CD46 protein (Recombinant) (C-His) (STJP001049)

  • 產(chǎn)品型號(hào)：STJP001049
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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Human CD46 protein (Recombinant) (C-His) (STJP001049)
詳情介紹：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CD46-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Gene Symbol: CD46
Gene ID: 4179
Uniprot ID: MCP_HUMAN
Immunogen Region: Cys35-Asp328
Immunogen: Recombinant Human CD46 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Cys35-Asp328) of human CD46 (Accession #NP_758861.1) fused with a 6×His tag at the C-terminus.
Tissue Specificity Expressed by all cells except erythrocytes.
Post Translational Modifications N-glycosylated on Asn-83.Asn-114 and Asn-273 in most tissues, but probably less N-glycosylated in testis. N-glycosylation on Asn-114 and Asn-273 is required for cytoprotective function. N-glycosylation on Asn-114 is required for Measles virus binding. N-glycosylation on Asn-273 is required for Neisseria binding. N-glycosylation is not required for human adenovirus binding. Extensively O-glycosylated in the Ser/Thr-rich domain. O-glycosylation is required for Neisseria binding but not for Measles virus or human adenovirus binding. In epithelial cells, isoforms B/D/F/H/J/L/3 are phosphorylated by YES1 in response to infection by Neisseria gonorrhoeae.which promotes infectivity. In T-cells, these isoforms may be phosphorylated by LCK.
Function Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells. (Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3. (Microbial infection) Acts as a receptor for cultured Measles virus. (Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6. (Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes.
Protein Name Membrane Cofactor Protein
Tlx
Trophoblast Leukocyte Common Antigen
Cd Antigen Cd46
Database Links Reactome: R-HSA-977606
Cellular Localisation Cytoplasmic Vesicle
Secretory Vesicle
Acrosome Inner Membrane
Single-Pass Type I Membrane Protein
Inner Acrosomal Membrane Of Spermatozoa
Internalized Upon Binding Of Measles Virus
Herpesvirus 6 Or Neisseria Gonorrhoeae
Which Results In An Increased Susceptibility Of Infected Cells To Complement-Mediated Injury
In Cancer Cells Or Cells Infected By Neisseria
Shedding Leads To A Soluble Peptide
Alternative Protein Names Membrane Cofactor Protein protein
Tlx protein
Trophoblast Leukocyte Common Antigen protein
Cd Antigen Cd46 protein
CD46 protein
MCP protein
MIC10 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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