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產(chǎn)品詳情

  • 產(chǎn)品名稱：Human CD45/PTPRC protein (Recombinant) (C-His-Avi) {Biotin} (STJP001724)

  • 產(chǎn)品型號(hào)：STJP001724
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
Human CD45/PTPRC protein (Recombinant) (C-His-Avi) {Biotin} (STJP001724)
詳情介紹：
Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CD45/PTPRC-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 μm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/μg (1EU/μg).
Gene Symbol: PTPRC
Gene ID: 5788
Uniprot ID: PTPRC_HUMAN
Immunogen Region: Gln26?≠-Lys416
Immunogen: DNA sequence encoding Human CD45/PTPRC including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Post Translational Modifications Heavily N- and O-glycosylated.
Function Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation.
Protein Name Receptor-Type Tyrosine-Protein Phosphatase C
Leukocyte Common Antigen
L-Ca
T200
Cd Antigen Cd45
Database Links Reactome: R-HSA-202427
Reactome: R-HSA-416700
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Membrane Raft
Colocalized With Dpp4 In Membrane Rafts
Alternative Protein Names Receptor-Type Tyrosine-Protein Phosphatase C protein
Leukocyte Common Antigen protein
L-Ca protein
T200 protein
Cd Antigen Cd45 protein
PTPRC protein
CD45 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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