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產(chǎn)品詳情

  • 產(chǎn)品名稱：Human CD33 (Siglec-3) protein (Recombinant) {Biotin} (STJP000204)

  • 產(chǎn)品型號：STJP000204
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
Human CD33 (Siglec-3) protein (Recombinant) {Biotin} (STJP000204)
詳情介紹：
Host: HEK293
Applications: ELISA/WB
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CD33 (Siglec-3)-protein was developed from hek293. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose.
Storage Instruction: Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/μg (1EU/μg). NA
Gene Symbol: CD33
Gene ID: 945
Uniprot ID: CD33_HUMAN
Immunogen Region: ECD
Immunogen: Optimized DNA sequence encoding extracellular domain of Human CD33 including a C-terminal His tag was expressed in HEK293 cells. CD33 was further labled by Biotin for detection by avidin conjugated secondary probes. NA
Tissue Specificity Monocytic/myeloid lineage cells. In the brain, CD33 is mainly expressed on microglial cells.
Post Translational Modifications Glycosylated. Glycosylation at Asn-100 is critical for regulating ligand recognition. Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6. LCK phosphorylates Tyr-340 efficiently and Tyr-358 to a lesser extent.
Function Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans. Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules. One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K.
Protein Name Myeloid Cell Surface Antigen Cd33
Sialic Acid-Binding Ig-Like Lectin 3
Siglec-3
Gp67
Cd Antigen Cd33
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-6798695
Cellular Localisation Isoform Cd33m: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform Cd33m: Peroxisome
Cd33m Isoform Does Not Localize To Cell Surfaces But Instead Accumulates In Peroxisomes
Alternative Protein Names Myeloid Cell Surface Antigen Cd33 protein
Sialic Acid-Binding Ig-Like Lectin 3 protein
Siglec-3 protein
Gp67 protein
Cd Antigen Cd33 protein
CD33 protein
SIGLEC3 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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