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簡單介紹：

CCR4 Blocking Peptide peptide (STJ503784)

詳情介紹：

Applications:	Immunodepletion/Immunocompetition
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	CCR4 Blocking Peptide is synthetically produced from the 1-50 aa sequence and is suitable for use in western blot applications.

Formulation:	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	CCR4
Gene ID:	1233
Uniprot ID:	CCR4_HUMAN
Immunogen Region:	1-50 aa
Immunogen:	Synthetic peptide taken within amino acid region 1-50 on human C-C chemokine receptor type 4 protein.

Tissue Specificity	Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets.at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells.
Post Translational Modifications	In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.
Function	High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
Peptide Name	C-C Chemokine Receptor Type 4 C-C Ckr-4 Cc-Ckr-4 Ccr-4 Ccr4 K5-5 Cd Antigen Cd194
Database Links	Reactome: R-HSA-380108 Reactome: R-HSA-418594
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein
Alternative Peptide Names	C-C Chemokine Receptor Type 4 protein C-C Ckr-4 protein Cc-Ckr-4 protein Ccr-4 protein Ccr4 protein K5-5 protein Cd Antigen Cd194 protein CCR4 protein CMKBR4 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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