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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-ACADL antibody (31-210) (STJ22475)

  • 產(chǎn)品型號(hào)：STJ22475
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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Anti-ACADL antibody (31-210) (STJ22475)
詳情介紹：
Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ACADL (31-210) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ACADL
Gene ID: 33
Uniprot ID: ACADL_HUMAN
Immunogen Region: 31-210
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 31-210 of human ACADL (NP_001599.1).
Immunogen Sequence: GGEERLETPSAKKLTDIGIR RIFSPEHDIFRKSVRKFFQE EVIPHHSEWEKAGEVSREVW EKAGKQGLLGVNIAEHLGGI GGDLYSAAIVWEEQAYSNCS GPGFSIHSGIVMSYITNHGS EEQIKHFIPQMTAGKCIGAI AMTEPGAGSDLQGIKTNAKK DGSDWILNGSKVFISNGSLS
Post Translational Modifications Acetylation at Lys-318 and Lys-322 in proximity of the cofactor-binding sites strongly reduces catalytic activity. These sites are deacetylated by SIRT3.
Function Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase can act on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains.
Protein Name Long-Chain Specific Acyl-Coa Dehydrogenase - Mitochondrial
Lcad
Database Links Reactome: R-HSA-77285
Reactome: R-HSA-77288
Reactome: R-HSA-77310
Cellular Localisation Mitochondrion Matrix
Alternative Antibody Names Anti-Long-Chain Specific Acyl-Coa Dehydrogenase - Mitochondrial antibody
Anti-Lcad antibody
Anti-ACADL antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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