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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-ABCA4 Rim Protein antibody [3F4] (STJA0003574)

  • 產(chǎn)品型號(hào)：STJA0003574-100
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
Anti-ABCA4 Rim Protein antibody [3F4] (STJA0003574)
詳情介紹：
Host: Mouse
Applications: WB/IHC
Reactivity: Bovine/Human/Mouse/Xenopus
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-ABCA4 Rim Protein is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: 3F4
Conjugation: Unconjugated
Isotype: IgG1
Formulation: 100 μl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 μg per ml BSA and 50% Glycerol.
Purification: This antibody was protein g purified culture from supernatant.
Dilution Range: WB 1:1000
IHC 1:100
ICC
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Abca4
Gene ID: 11304
Uniprot ID: ABCA4_MOUSE
Immunogen: Partially purification bovine 220-kDa disc rim protein.
Tissue Specificity Retinal-specific. Seems to be exclusively found in the rims of rod photoreceptor cells.
Post Translational Modifications N-glycosylated. Proteolytic cleavage by trypsin leads to a 120-kDa N-terminal fragment and a 115-kDa C-terminal fragment that are linked through disulfide bonds. Phosphorylation is independent of light exposure and modulates ATPase activity.
Function Flippase that catalyzes in an ATP-dependent manner the transport of retinal-phosphatidylethanolamine conjugates like the 11-cis and all-trans isomers of N-retinylidene-phosphatidylethanolamine from the lumen to the cytoplasmic leaflet of photoreceptor outer segment disk membranes, where N-cis-retinylidene-phosphatidylethanolamine (N-cis-R-PE) is then isomerized to its all-trans isomer (N-trans-R-PE) and reduced by RDH8 to produce all-trans-retinol (all-trans-rol) and therefore prevents the accumulation of excess of 11-cis-retinal and its schiff-base conjugate and the formation of toxic bisretinoid. Displays both ATPase and GTPase activity that is strongly influenced by the lipid environment and the presence of retinoid compounds. Binds the unprotonated form of N-retinylidene-phosphatidylethanolamine with high affinity in the absence of ATP and ATP binding and hydrolysis induce a protein conformational change that causes the dissociation of N-retinylidene-phosphatidylethanolamine.
Protein Name Retinal-Specific Phospholipid-Transporting Atpase Abca4
Atp-Binding Cassette Sub-Family A Member 4
Rim Abc Transporter
Rim Protein
Rmp
Retinal-Specific Atp-Binding Cassette Transporter
Database Links Reactome: R-MMU-2453902
Reactome: -MMU-382556
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Endoplasmic Reticulum
Cell Projection
Cilium
Photoreceptor Outer Segment
Localized To The Rim And Incisures Of Rod Outer Segments Disks
Alternative Antibody Names Anti-Retinal-Specific Phospholipid-Transporting Atpase Abca4 antibody
Anti-Atp-Binding Cassette Sub-Family A Member 4 antibody
Anti-Rim Abc Transporter antibody
Anti-Rim Protein antibody
Anti-Rmp antibody
Anti-Retinal-Specific Atp-Binding Cassette Transporter antibody
Anti-Abca4 antibody
Anti-Abcr antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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