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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-ABCA4 antibody (1336-49) (STJ71853)

  • 產(chǎn)品型號：STJ71853-100
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
Anti-ABCA4 antibody (1336-49) (STJ71853)
詳情介紹：
Host: Goat
Applications: Pep-ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-ABCA4 (1336-49) is suitable for use in ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: ELISA-antibody detection limit dilution 1:32000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: ABCA4
Gene ID: 24
Uniprot ID: ABCA4_HUMAN
Immunogen Region: 1336-49
Accession Number: NP_000341.2
Immunogen Sequence: EPECPGPQLNTGTQ
Post Translational Modifications Proteolytic cleavage by trypsin leads to a 120-kDa N-terminal fragment and a 115-kDa C-terminal fragment that are linked through disulfide bonds. N-glycosylated. Phosphorylation is independent of light exposure and modulates ATPase activity.
Function Flippase that catalyzes in an ATP-dependent manner the transport of retinal-phosphatidylethanolamine conjugates like the 11-cis and all-trans isomers of N-retinylidene-phosphatidylethanolamine from the lumen to the cytoplasmic leaflet of photoreceptor outer segment disk membranes, where N-cis-retinylidene-phosphatidylethanolamine (N-cis-R-PE) is then isomerized to its all-trans isomer (N-trans-R-PE) and reduced by RDH8 to produce all-trans-retinol (all-trans-rol) and therefore prevents the accumulation of excess of 11-cis-retinal and its schiff-base conjugate and the formation of toxic bisretinoid. May display both ATPase and GTPase activity that is strongly influenced by the lipid environment and the presence of retinoid compounds. Binds the unprotonated form of N-retinylidene-phosphatidylethanolamine with high affinity in the absence of ATP, and ATP binding and hydrolysis induce a protein conformational change that causes the dissociation of N-retinylidene-phosphatidylethanolamine.
Protein Name Retinal-Specific Phospholipid-Transporting Atpase Abca4
Atp-Binding Cassette Sub-Family A Member 4
Rim Abc Transporter
Rim Proteinv
Rmp
Retinal-Specific Atp-Binding Cassette Transporter
Stargardt Disease Protein
Database Links Reactome: R-HSA-2453864
Reactome: R-HSA-2453902
Reactome: R-HSA-382556
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Endoplasmic Reticulum
Cytoplasmic Vesicle
Cell Projection
Cilium
Photoreceptor Outer Segment
Localized To The Rim And Incisures Of Rod Outer Segments Disks
Alternative Antibody Names Anti-Retinal-Specific Phospholipid-Transporting Atpase Abca4 antibody
Anti-Atp-Binding Cassette Sub-Family A Member 4 antibody
Anti-Rim Abc Transporter antibody
Anti-Rim Proteinv antibody
Anti-Rmp antibody
Anti-Retinal-Specific Atp-Binding Cassette Transporter antibody
Anti-Stargardt Disease Protein antibody
Anti-ABCA4 antibody
Anti-ABCR antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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