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產(chǎn)品名稱：Human Fas ligand/APTL/CD95 ligand/CD178 protein (Recombinant) (N-His) (STJP002146)
產(chǎn)品型號：STJP002146
產(chǎn)品廠商：ST john's laboratory
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Human Fas ligand/APTL/CD95 ligand/CD178 protein (Recombinant) (N-His) (STJP002146)

詳情介紹：

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human Fas ligand/APTL/CD95 ligand/CD178-N-His protein was developed from hek293 cells and has a target region of N-His. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FASLG
Gene ID:	356
Uniprot ID:	TNFL6_HUMAN
Immunogen Region:	Pro134-Leu281
Immunogen:	Recombinant Human Fas ligand/APTL/CD95 ligand/CD178 Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Pro134-Leu281) of Human Fas Ligand (monomer) fused with a His tag at the N-terminal.

Function	Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. Tumor necrosis factor ligand superfamily member 6, soluble form: Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways. Can induce apoptosis but does not appear to be essential for this process. FasL intracellular domain: Cytoplasmic form induces gene transcription inhibition.
Protein Name	Tumor Necrosis Factor Ligand Superfamily Member 6 Apoptosis Antigen Ligand Aptl Cd95 Ligand Cd95-L Fas Antigen Ligand Fas Ligand Fasl Cd Antigen Cd178 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 6 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 6 - Soluble Form Receptor-Binding Fasl Ectodomain Soluble Fas Ligand Sfasl - Adam10-Processed Fasl Form Apl - Fasl Intracellular Domain Fasl Icd Sppl2a-Processed Fasl Form Spa
Database Links	Reactome: R-HSA-140534 Reactome: R-HSA-3371378 Reactome: R-HSA-5213460 Reactome: R-HSA-5218900 Reactome: R-HSA-6785807 Reactome: R-HSA-69416 Reactome: R-HSA-75157 Reactome: R-HSA-8862803 Reactome: R-HSA-9614657
Cellular Localisation	Cell Membrane Single-Pass Type Ii Membrane Protein Cytoplasmic Vesicle Lumen Lysosome Lumen Is Internalized Into Multivesicular Bodies Of Secretory Lysosomes After Phosphorylation By Fgr And Monoubiquitination Colocalizes With The Sppl2a Protease At The Cell Membrane Tumor Necrosis Factor Ligand Superfamily Member 6 Soluble Form: Secreted May Be Released Into The Extracellular Fluid By Cleavage From The Cell Surface Fasl Intracellular Domain: Nucleus The Fasl Icd Cytoplasmic Form Is Translocated Into The Nucleus
Alternative Protein Names	Tumor Necrosis Factor Ligand Superfamily Member 6 protein Apoptosis Antigen Ligand protein Aptl protein Cd95 Ligand protein Cd95-L protein Fas Antigen Ligand protein Fas Ligand protein Fasl protein Cd Antigen Cd178 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 6 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 6 - Soluble Form protein Receptor-Binding Fasl Ectodomain protein Soluble Fas Ligand protein Sfasl - Adam10-Processed Fasl Form protein Apl - Fasl Intracellular Domain protein Fasl Icd protein Sppl2a-Processed Fasl Form protein Spa protein FASLG protein APT1LG1 protein CD95L protein FASL protein TNFSF6 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產(chǎn)品名稱：Human Fas ligand/APTL/CD95 ligand/CD178 protein (Recombinant) (N-His) (STJP002146)