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產(chǎn)品詳情

  • 產(chǎn)品名稱：Human Ephrin-B2/EFNB2 protein (Recombinant) (C-His) (STJP002561)

  • 產(chǎn)品型號：STJP002561
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
Human Ephrin-B2/EFNB2 protein (Recombinant) (C-His) (STJP002561)
詳情介紹：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Ephrin-B2/EFNB2-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human EFNB2 at 0.5 Mu g/mL (100 Mu L/well) can bind Human EPHB4 with a linear range of 6-400 pg/mL.
Gene Symbol: EFNB2
Gene ID: 1948
Uniprot ID: EFNB2_HUMAN
Immunogen Region: Ile28-Ala229
Immunogen: Recombinant Human Ephrin-B2/EFNB2 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Ile28-Ala229) of human Ephrin-B2/EFNB2 (Accession #NP_004084.1) fused with a 6×His tag at the C-terminus.
Post Translational Modifications Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.
Function Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. (Microbial infection) Acts as a receptor for Hendra virus and Nipah virus.
Protein Name Ephrin-B2
Eph-Related Receptor Tyrosine Kinase Ligand 5
Lerk-5
Htk Ligand
Htk-L
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-3928662
Reactome: R-HSA-3928664
Reactome: R-HSA-3928665
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Adherens Junction
Alternative Protein Names Ephrin-B2 protein
Eph-Related Receptor Tyrosine Kinase Ligand 5 protein
Lerk-5 protein
Htk Ligand protein
Htk-L protein
EFNB2 protein
EPLG5 protein
HTKL protein
LERK5 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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