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產(chǎn)品詳情

  • 產(chǎn)品名稱：Human Ephrin-B1/EFNB1 protein (Recombinant) (C-His) (STJP000868)

  • 產(chǎn)品型號(hào)：STJP000868
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
Human Ephrin-B1/EFNB1 protein (Recombinant) (C-His) (STJP000868)
詳情介紹：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Ephrin-B1/EFNB1-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human EFNB1 at 0.5 Mu g/mL (100 Mu L/well) can bind Mouse EPHB3 with a linear range of 0.1-3.5 ng/mL.
Gene Symbol: EFNB1
Gene ID: 1947
Uniprot ID: EFNB1_HUMAN
Immunogen: Recombinant Human Ephrin-B1/EFNB1 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Leu 28-Gly 232 ) of human Ephrin-B1 (Accession #NP_004420.1) fused with a 6×His tag at the C-terminus.
Tissue Specificity Widely expressed. Detected in both neuronal and non-neuronal tissues. Seems to have particularly strong expression in retina, sciatic nerve, heart and spinal cord.
Post Translational Modifications Inducible phosphorylation of tyrosine residues in the cytoplasmic domain. Proteolytically processed. The ectodomain is cleaved, probably by a metalloprotease, to produce a membrane-tethered C-terminal fragment. This fragment is then further processed by the gamma-secretase complex to yield a soluble intracellular domain peptide which can translocate to the nucleus. The intracellular domain peptide is highly labile suggesting that it is targeted for degradation by the proteasome.
Function Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells. Shows high affinity for the receptor tyrosine kinase EPHB1/ELK. Can also bind EPHB2 and EPHB3. Binds to, and induces collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons.
Protein Name Ephrin-B1
Efl-3
Elk Ligand
Elk-L
Eph-Related Receptor Tyrosine Kinase Ligand 2
Lerk-2 Cleaved Into - Ephrin-B1 C-Terminal Fragment
Ephrin-B1 Ctf - Ephrin-B1 Intracellular Domain
Ephrin-B1 Icd
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-3928662
Reactome: R-HSA-3928664
Reactome: R-HSA-3928665
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Membrane Raft
May Recruit Grip1 And Grip2 To Membrane Raft Domains
Ephrin-B1 C-Terminal Fragment: Cell Membrane
Ephrin-B1 Intracellular Domain: Nucleus
Colocalizes With Zhx2 In The Nucleus
Alternative Protein Names Ephrin-B1 protein
Efl-3 protein
Elk Ligand protein
Elk-L protein
Eph-Related Receptor Tyrosine Kinase Ligand 2 protein
Lerk-2 Cleaved Into - Ephrin-B1 C-Terminal Fragment protein
Ephrin-B1 Ctf - Ephrin-B1 Intracellular Domain protein
Ephrin-B1 Icd protein
EFNB1 protein
EFL3 protein
EPLG2 protein
LERK2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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