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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-ACTH antibody (25-39aa) [ZM98] (STJ180333)

  • 產(chǎn)品型號(hào)：STJ180333
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
Anti-ACTH antibody (25-39aa) [ZM98] (STJ180333)
詳情介紹：
Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-ACTH (25-39aa) is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: ZM98
Conjugation: Unconjugated
Isotype: IgG1/Kappa
Formulation: Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% proclin<="" td="">
Purification: Affinity purified
Dilution Range: 1:100‐200
Storage Instruction: Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.
Gene Symbol: ACTG2
Gene ID: 72
Uniprot ID: ACTH_HUMAN
Immunogen Region: 25-39aa
Specificity: Positive control: Pituitary
Immunogen: Synthetic peptide corresponding to aa 25-39 of human ACTH (NGAEDESAEAFPLEF)
Tissue Specificity In the intestine, abundantly expressed in smooth muscle cells of muscularis mucosa and muscularis propria. Also detected in intestinal vascular smooth muscle cells.
Post Translational Modifications Oxidation of Met-45 and Met-48 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization. Actin, gamma-enteric smooth muscle, intermediate form: N-terminal cleavage of acetylated cysteine of intermediate muscle actin by ACTMAP. Monomethylation at Lys-85 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. Methylated at His-74 by SETD3. (Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-51 of one monomer and Glu-271 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding. The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners.
Function Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Protein Name Actin - Gamma-Enteric Smooth Muscle
Alpha-Actin-3
Gamma-2-Actin
Smooth Muscle Gamma-Actin Cleaved Into - Actin - Gamma-Enteric Smooth Muscle - Intermediate Form
Database Links Reactome: R-HSA-445355
Cellular Localisation Cytoplasm
Cytoskeleton
Alternative Antibody Names Anti-Actin - Gamma-Enteric Smooth Muscle antibody
Anti-Alpha-Actin-3 antibody
Anti-Gamma-2-Actin antibody
Anti-Smooth Muscle Gamma-Actin Cleaved Into - Actin - Gamma-Enteric Smooth Muscle - Intermediate Form antibody
Anti-ACTG2 antibody
Anti-ACTA3 antibody
Anti-ACTL3 antibody
Anti-ACTSG antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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