產(chǎn)品詳情
簡單介紹：
EDG8 Positive Control for STJ502856 peptide (STJ505111)
詳情介紹：
| Applications: | WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | EDG8 Positive Control for STJ502856 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: | WB: 1:500 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | S1pr5 |
| Gene ID: | 60399 |
| Uniprot ID: | S1PR5_RAT |
| Specificity: | This is positive control is recommended for use in combination with EDG8 antibody STJ502856. |
| Tissue Specificity | Found almost exclusively in brain and skin. Ubiquitously detected in different brain regions with very prominent expression in lower brain regions such as the midbrain, pons, medulla, and spinal cord. Expressed predominantly within white matter tracts of the brain. Corpus callosum, optic nerve, olfactory tract, anterior commissure, internal and external capsules, fimbra of the hippocampus, mammillary tract, stria medullaris, and white matter of the cerebellum and brain stem all express the receptor. Within the striatum itself white matter fascicles express the receptor. Detected also in spleen and lung. Not observed in heart, liver, skeletal muscle, kidney, or testes. |
| Function | Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/O)alpha and G(12) subclass of heteromeric G-proteins. Displays antiproliferative effects in transfected CHO-K1 and HEK293 cells. |
| Peptide Name | Sphingosine 1-Phosphate Receptor 5 S1p Receptor 5 S1p5 Endothelial Differentiation G-Protein-Coupled Receptor 8 Nerve Growth Factor-Regulated G-Protein-Coupled Receptor 1 Nrg-1 Sphingosine 1-Phosphate Receptor Edg-8 S1p Receptor Edg-8 |
| Database Links | Reactome: R-RNO-418594 Reactome: -RNO-419408 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein |
| Alternative Peptide Names | Sphingosine 1-Phosphate Receptor 5 protein S1p Receptor 5 protein S1p5 protein Endothelial Differentiation G-Protein-Coupled Receptor 8 protein Nerve Growth Factor-Regulated G-Protein-Coupled Receptor 1 protein Nrg-1 protein Sphingosine 1-Phosphate Receptor Edg-8 protein S1p Receptor Edg-8 protein S1pr5 protein Edg8 protein Nrg1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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