產(chǎn)品詳情
簡單介紹：
EAAT2 Blocking Peptide peptide (STJ504939)
詳情介紹：
| Applications: | Immunodepletion/Immunocompetition |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | EAAT2 Blocking Peptide is synthetically produced from the 550-574 sequence and is suitable for use in western blot applications. |
| Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | SLC1A2 |
| Gene ID: | 6506 |
| Uniprot ID: | EAA2_HUMAN |
| Immunogen Region: | 550-574 |
| Immunogen: | Synthetic peptide corresponding to C terminal amino acids 550-574 of Human EAAT2. Sequence: KVTLAANGKSADCSVEEEPWKREK |
| Post Translational Modifications | Glycosylated. Palmitoylation at Cys-38 is not required for correct subcellular localization, but is important for glutamate uptake activity. |
| Function | Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport.this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate. |
| Peptide Name | Excitatory Amino Acid Transporter 2 Glutamate/Aspartate Transporter Ii Sodium-Dependent Glutamate/Aspartate Transporter 2 Solute Carrier Family 1 Member 2 |
| Database Links | Reactome: R-HSA-210455 Reactome: R-HSA-210500 Reactome: R-HSA-425393 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein |
| Alternative Peptide Names | Excitatory Amino Acid Transporter 2 protein Glutamate/Aspartate Transporter Ii protein Sodium-Dependent Glutamate/Aspartate Transporter 2 protein Solute Carrier Family 1 Member 2 protein SLC1A2 protein EAAT2 protein GLT1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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