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產(chǎn)品名稱：Human Ep-CAM/TROP-1/CD326 protein (Recombinant) (C-His) (STJP000849)
產(chǎn)品型號：STJP000849
產(chǎn)品廠商：ST john's laboratory
產(chǎn)品文檔：

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Human Ep-CAM/TROP-1/CD326 protein (Recombinant) (C-His) (STJP000849)

詳情介紹：

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human Ep-CAM/TROP-1/CD326-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity:	Measured by the ability of the immobilized protein to support the adhesion of NIH-3T3 mouse embryonic fibroblast cells. When cells are added to EpCAM-His coated plates (1.25 Mu g/mL, 100 Mu L/well) , approximately >30% will adhere specifically after

Gene Symbol:	EPCAM
Gene ID:	4072
Uniprot ID:	EPCAM_HUMAN
Immunogen:	Recombinant Human Ep-CAM/TROP-1/CD326 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln24-Lys265) of human EpCAM/TROP-1 (Accession #NP_002345.2) fused with a 6×His tag at the C-terminus.

Tissue Specificity	Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma.
Post Translational Modifications	Hyperglycosylated in carcinoma tissue as compared with autologous normal epithelia. Glycosylation at Asn-198 is crucial for protein stability.
Function	May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
Protein Name	Epithelial Cell Adhesion Molecule Ep-Cam Adenocarcinoma-Associated Antigen Cell Surface Glycoprotein Trop-1 Epithelial Cell Surface Antigen Epithelial Glycoprotein Egp Epithelial Glycoprotein 314 Egp314 Hegp314 Ks 1/4 Antigen Ksa Major Gastrointestinal Tumor-Associated Protein Ga733-2 Tumor-Associated Calcium Signal Transducer 1 Cd Antigen Cd326
Database Links	Reactome: R-HSA-202733
Cellular Localisation	Lateral Cell Membrane Single-Pass Type I Membrane Protein Cell Junction Tight Junction Colocalizes With Cldn7 At The Lateral Cell Membrane And Tight Junction
Alternative Protein Names	Epithelial Cell Adhesion Molecule protein Ep-Cam protein Adenocarcinoma-Associated Antigen protein Cell Surface Glycoprotein Trop-1 protein Epithelial Cell Surface Antigen protein Epithelial Glycoprotein Egp protein Epithelial Glycoprotein 314 protein Egp314 protein Hegp314 protein Ks 1/4 Antigen protein Ksa protein Major Gastrointestinal Tumor-Associated Protein Ga733-2 protein Tumor-Associated Calcium Signal Transducer 1 protein Cd Antigen Cd326 protein EPCAM protein GA733-2 protein M1S2 protein M4S1 protein MIC18 protein TACSTD1 protein TROP1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產(chǎn)品名稱：Human Ep-CAM/TROP-1/CD326 protein (Recombinant) (C-His) (STJP000849)