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產品詳情

  • 產品名稱：Human DPP4 (CD26) protein (Recombinant) (STJP000496)

  • 產品型號：STJP000496
  • 產品廠商：ST john's laboratory
  • 產品文檔：
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簡單介紹：
Human DPP4 (CD26) protein (Recombinant) (STJP000496)
詳情介紹：
Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human DPP4 (CD26)-protein was developed from hek293. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose.
Storage Instruction: Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/μg (1EU/μg). NA
Gene Symbol: DPP4
Gene ID: 1803
Uniprot ID: DPP4_HUMAN
Immunogen Region: ECD
Immunogen: Optimized DNA sequence encoding extracellular domain of Human CD26 including a C-terminal His tag was expressed in HEK293 cells. NA
Tissue Specificity Expressed specifically in lymphatic vessels but not in blood vessels in the skin, small intestine, esophagus, ovary, breast and prostate glands. Not detected in lymphatic vessels in the lung, kidney, uterus, liver and stomach (at protein level). Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon.
Post Translational Modifications The soluble form (Dipeptidyl peptidase 4 soluble form also named SDPP) derives from the membrane form (Dipeptidyl peptidase 4 membrane form also named MDPP) by proteolytic processing. N- and O-Glycosylated. Phosphorylated. Mannose 6-phosphate residues in the carbohydrate moiety are necessary for interaction with IGF2R in activated T-cells. Mannose 6-phosphorylation is induced during T-cell activation.
Function Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones such as brain natriuretic peptide 32. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. (Microbial infection) Acts as a receptor for human coronavirus MERS-CoV-2.
Protein Name Dipeptidyl Peptidase 4
Adabp
Adenosine Deaminase Complexing Protein 2
Adcp-2
Dipeptidyl Peptidase Iv
Dpp Iv
T-Cell Activation Antigen Cd26
Tp103
Cd Antigen Cd26 Cleaved Into - Dipeptidyl Peptidase 4 Membrane Form
Dipeptidyl Peptidase Iv Membrane Form - Dipeptidyl Peptidase 4 Soluble Form
Dipeptidyl Peptidase Iv Soluble Form
Database Links Reactome: R-HSA-381771
Reactome: R-HSA-400511
Cellular Localisation Dipeptidyl Peptidase 4 Soluble Form: Secreted
Detected In The Serum And The Seminal Fluid
Cell Membrane
Single-Pass Type Ii Membrane Protein
Apical Cell Membrane
Cell Projection
Invadopodium Membrane
Lamellipodium Membrane
Cell Junction
Membrane Raft
Translocated To The Apical Membrane Through The Concerted Action Of N- And O-Glycans And Its Association With Lipid Microdomains Containing Cholesterol And Sphingolipids
Redistributed To Membrane Rafts In T-Cell In An Interleukin-12-Dependent Activation
Its Interaction With Cav1 Is Necessary For Its Translocation To Membrane Rafts
Colocalized With Ptprc In Membrane Rafts
Colocalized With Fap In Invadopodia And Lamellipodia Of Migratory Activated Endothelial Cells In Collagenous Matrix
Colocalized With Fap On Endothelial Cells Of Capillary-Like Microvessels But Not Large Vessels Within Invasive Breast Ductal Carcinoma
Colocalized With Ada At The Cell Junction In Lymphocyte-Epithelial Cell Adhesion
Colocalized With Igf2r In Internalized Cytoplasmic Vesicles Adjacent To The Cell Surface
Alternative Protein Names Dipeptidyl Peptidase 4 protein
Adabp protein
Adenosine Deaminase Complexing Protein 2 protein
Adcp-2 protein
Dipeptidyl Peptidase Iv protein
Dpp Iv protein
T-Cell Activation Antigen Cd26 protein
Tp103 protein
Cd Antigen Cd26 Cleaved Into - Dipeptidyl Peptidase 4 Membrane Form protein
Dipeptidyl Peptidase Iv Membrane Form - Dipeptidyl Peptidase 4 Soluble Form protein
Dipeptidyl Peptidase Iv Soluble Form protein
DPP4 protein
ADCP2 protein
CD26 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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